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Molecular Mechanisms of Parasite Invasion

  • Book
  • © 2008

Overview

Part of the book series: Subcellular Biochemistry (SCBI, volume 47)

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Table of contents (18 chapters)

  1. Tools and Experimental Approaches

  2. Receptor-Ligand Interaction

  3. Signaling Pathways

  4. Actin Dynamics: Host and Parasite

  5. Proteases

  6. The Parasitophorous Vacuole

  7. Penetrating Biological Barriers

Keywords

About this book

All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens—not only with regard to their clinical relevance but also the fascinating biology they reveal. For most of the parasites discussed here the ability to penetrate biological barriers and/or to establish intracellular residence is critical to survival of the pathogen in the mammalian hosts. For other parasites, a tissue invasive phenotype is a key virulence determinant. In the ensuing 18 chapters, select members of this diverse set of protozoan parasites, as well as some examples of the extremely reduced fungal parasites classified as Microsporidia, are discussed within the context of the fascinating molecular strategies employed by these organisms to migrate across biological barriers and to establish residence within target host cells.

Reviews

From the reviews:

"An environment in which there is extensive knowledge of the DNA, RNA and protein of key parasites and of human cells. … Readers of this book will discover that while many of the exact mechanisms … adopted by different parasites. As someone working in this field I found this book enormously interesting and useful … . Active researchers and PhD students in this and affiliated fields will no doubt find this an essential resource for several years … ." (Kevin M. Tyler, Parasites and Vectors, Issue 2, May, 2009)

Editors and Affiliations

  • Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, USA

    Barbara A. Burleigh

  • Department of Biological Sciences, Imperial College, London, UK

    Dominique Soldati-Favre

  • Département de Microbiologie et Medecine Moléculaire, Université de Genève, Geneve, Switzerland

    Dominique Soldati-Favre

Bibliographic Information

  • Book Title: Molecular Mechanisms of Parasite Invasion

  • Editors: Barbara A. Burleigh, Dominique Soldati-Favre

  • Series Title: Subcellular Biochemistry

  • DOI: https://doi.org/10.1007/978-0-387-78267-6

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag New York 2008

  • Hardcover ISBN: 978-0-387-78266-9Published: 17 April 2008

  • Softcover ISBN: 978-1-4419-2683-8Published: 19 November 2010

  • eBook ISBN: 978-0-387-78267-6Published: 05 December 2008

  • Series ISSN: 0306-0225

  • Series E-ISSN: 2542-8810

  • Edition Number: 1

  • Number of Pages: XX, 237

  • Number of Illustrations: 48 b/w illustrations, 4 illustrations in colour

  • Topics: Biomedicine general

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