Skip to main content
  • Book
  • © 2008

Drug Targets in Kinetoplastid Parasites

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 625)

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

This is a preview of subscription content, log in via an institution to check for access.

Table of contents (12 chapters)

  1. Front Matter

    Pages i-xix
  2. Arsenite Resistance in Leishmania and Possible Drug Targets

    • Gaganmeet Singh, K. G. Jayanarayan, Chinmoy S. Dey
    Pages 1-8
  3. Unique Characteristics of the Kinetoplast DNA Replication Machinery Provide Potential Drug Targets in Trypanosomatids

    • Dotan Sela, Neta Milman, Irit Kapeller, Aviad Zick, Rachel Bezalel, Nurit Yaffe et al.
    Pages 9-21
  4. Selective Lead Compounds against Kinetoplastid Tubulin

    • R.E. Morgan, K.A. Werbovetz*
    Pages 33-47
  5. Fishing for Anti-Leishmania Drugs: Principles and Problems

    • Emanuela Handman, Lukasz Kedzierski, Alessandro D. Uboldi, James W. Goding
    Pages 48-60
  6. Histone Deacetylases

    • David Horn
    Pages 81-86
  7. Targeting Glycoproteins or Glycolipids and Their Metabolic Pathways for Antiparasite Therapy

    • Sumi Mukhopadhyay nee Bandyopadhyay, Chitra Mandal
    Pages 87-102
  8. DNA Topoisomerases of Leishmania: The Potential Targets for Anti-Leishmanial Therapy

    • Benu Brata Das, Agneyo Ganguly, Hemanta K. Majumder
    Pages 103-115
  9. Antiparasitic Chemotherapy:

    • Alok Kumar Datta, Rupak Datta, Banibrata Sen
    Pages 116-132
  10. Searching the Tritryp Genomes for Drug Targets

    • Peter J. Myler
    Pages 133-140
  11. Purine and Pyrimidine Metabolism in Leishmania

    • Nicola S. Carter, Phillip Yates, Cassandra S. Arendt, Jan M. Boitz, Buddy Ullman
    Pages 141-154
  12. Back Matter

    Pages 155-157

About this book

If viewed globally, the parasitic diseases pose an increasing threat to human health and welfare. The diseases caused by kinetoplastid protozoan parasites like Leishmania and Trypanosoma continue as a cause of suffering for many millions of people in both tropical and subtropical regions of the world. Leishmania species are found throughout Latin America, Africa and Asia. Trypanosoma cruzi that cause Chagas’ disease is endemic in Latin America, while members of Trypanosoma brucei group are found in sub-Saharan Africa. Although the past two decades has witnessed commendable research efforts and technical advances in our understanding of the biochemistry, molecular and cell biology of these pathogens, the dreaded protozoal diseases caused by these organisms threaten mankind. Therapeutic tools for the treatment of most parasitic diseases are extremely limited. The development of parasites resistant to many of the available drugs is also responsible for the depressing picture of disease persistence and death. Development of commercially available vaccines is still far from reality, though research and trial programs continue.

Editors and Affiliations

  • Molecular Parasitology Laboratory, Indian Institute of Chemical Biology, Kolkata, India

    Hemanta K. Majumder

Bibliographic Information

  • Book Title: Drug Targets in Kinetoplastid Parasites

  • Editors: Hemanta K. Majumder

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-0-387-77570-8

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2008

  • Hardcover ISBN: 978-0-387-77569-2Published: 23 January 2008

  • Softcover ISBN: 978-1-4419-2656-2Published: 24 January 2011

  • eBook ISBN: 978-0-387-77570-8Published: 15 September 2008

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XX, 158

  • Number of Illustrations: 44 b/w illustrations, 1 illustrations in colour

  • Topics: Parasitology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access