Overview
- Editors:
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Johannes W. Hell
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Department of Pharmacology 2-512 BSB, University of Iowa, Iowa City
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Michael D. Ehlers
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Department of Neurobiology, Duke University Medical Center, Durham
Deals directly with the different and specific aspects of synaptic function, unlike other available books which cover the fundamentals
Includes supplementary material: sn.pub/extras
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Table of contents (26 chapters)
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Front Matter
Pages I-XVIII
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- Johannes W. Hell, Michael D. Ehlers
Pages 1-22
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- Dwight E. Bergles, Robert H. Edwards
Pages 23-61
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- Craig C. Garner, Kang Shen
Pages 63-89
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- Deniz Atasoy, Ege T. Kavalali
Pages 91-110
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- Peter S. McPherson, Brigitte Ritter, George J. Augustine
Pages 111-146
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- Zu-Hang Sheng, Amy Lee, William A. Catterall
Pages 147-172
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- Cyril Hanus, Michael D. Ehlers
Pages 205-249
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- Hongjie Yuan, Matthew T. Geballe, Kasper B. Hansen, Stephen F. Traynelis
Pages 289-316
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- Robert J. Wenthold, Rana A. Al-Hallaq, Catherine Croft Swanwick, Ronald S. Petralia
Pages 317-367
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- Daniel Choquet, Antoine Triller
Pages 369-406
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- Mary B. Kennedy, Edoardo Marcora, Holly J. Carlisle
Pages 407-440
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- Bernardo L. Sabatini, Karel Svoboda
Pages 441-458
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- Stefan Strack, Johannes W. Hell
Pages 459-500
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- John E. Lisman, Johannes W. Hell
Pages 501-534
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- Thomas D. Helton, Michael D. Ehlers
Pages 553-600
About this book
The synapse is a fascinating structure for many reasons. Biologically, it is an exquisitely organized subcellular compartment that has a remarkable capacity for fidelity and endurance. Computationally, synapses play a central role in signal transmission and processing that represent evolution’s solution to learning and memory. Nervous systems, including our own brains, possess an extraordinary capacity for adaptation and memory because the synapse, not the neuron, constitutes the basic unit for information storage. Because the molecular complexities underlying signal processing and information storage must occur within the tiny space of the synapse, the precise molecular organization of proteins, lipids, and membranes at the synapse is paramount. Given the central role of the synapse in neuronal communication, it comes as no surprise that dysregulation of the synapse accounts for many, if not most, neurological and psychiatric disorders. Clinically, the synapse thus constitutes a prime target for treatments of these diseases. It is for these reasons that we have chosen to focus our work on deciphering the structural and functional organization of the synapse. We have assembled leaders in the field of synapse biology to describe and distill the wonders and mysteries of the synapse. This book provides a fundamental description of the synapse developed over many decades by numerous investigators, paired with recent insight into new aspects of synapse structure and function that is still in flux and at the cutting edge of research.
Editors and Affiliations
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Department of Pharmacology 2-512 BSB, University of Iowa, Iowa City
Johannes W. Hell
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Department of Neurobiology, Duke University Medical Center, Durham
Michael D. Ehlers
