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Drug Addiction

From Basic Research to Therapy

  • Book
  • © 2008

Overview

Editors:
  1. Rao S. Rapaka

    1. National Institute on Drug Abuse, Bethesda, USA

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  2. Wolfgang Sadée

    1. College of Medicine and Public Health, Ohio State University, Columbus, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Provides a comprehensive overview of physiological, biochemical, and genetic pathways underlying drug addiction, and resultant efforts to develop novel treatment strategies dealing with drug addiction and other CNS disorders where the neurophysiological processes overlap, such as treatment of pain

  • Focuses on the translation of fundamental addiction research to a variety of treatments, bringing together scientists with widely ranging expertise in synthetic and computational chemistry, molecular biology, genetics, and neuroscience with researchers in drug discovery and development, drug targeting, and quantitative therapeutics

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Table of contents (44 chapters)

  1. Front Matter

    Pages i-xxiii
    Download chapter PDF

  2. General Topics

    1. DARPP-32 Mediates the Actions of Multiple Drugs of Abuse

      • Per Svenningsson, Angus C. Nairn, Paul Greengard
      Pages 3-16

    2. Drug Discovery From Natural Sources

      • Young-Won Chin, Marcy J. Balunas, Hee Byung Chai, A. Douglas Kinghorn
      Pages 17-39

    3. Computational Methods in Drug Design: Modeling G Protein-Coupled Receptor Monomers, Dimers, and Oligomers

      • Patricia H. Reggio
      Pages 41-68

    4. Symbiotic Relationship of Pharmacogenetics and Drugs of Abuse

      • Joni L. Rutter
      Pages 69-86

    5. Monoclonal Antibody Form and Function: Manufacturing the Right Antibodies for Treating Drug Abuse

      • Eric Peterson, S. Michael Owens, Ralph L. Henry
      Pages 87-100

    6. Cocaine- and Amphetamine-Regulated Transcript Peptides Play a Role in Drug Abuse and Are Potential Therapeutic Targets

      • Michael J. Kuhar, Jason N. Jaworski, George W. Hubert, Kelly B. Philpot, Geraldina Dominguez
      Pages 101-112

    7. RNAi-Directed Inhibition of DC-SIGN by Dendritic Cells: Prospects for HIV-1 Therapy

      • Madhavan P. N. Nair, Jessica L. Reynolds, Supriya D. Mahajan, Stanley A. Schwartz, Ravikumar Aalinkeel, B. Bindukumar et al.
      Pages 113-125

    8. Viewing Chemokines as a Third Major System of Communication in the Brain

      • Martin W. Adler, Ellen B. Geller, Xiaohong Chen, Thomas J. Rogers
      Pages 127-138

    9. Targeting the PDZ Domains of Molecular Scaffolds of Transmembrane Ion Channels

      • Andrea Piserchio, Mark Spaller, Dale F. Mierke
      Pages 139-148

    10. Neuronal Nicotinic Acetylcholine Receptor Expression and Function on Nonneuronal Cells

      • Lorise C. Gahring, Scott W. Rogers
      Pages 149-166

  3. Transporters & Stimulants & Hallucinogens

    1. Role of Monoamine Transporters in Mediating Psychostimulant Effects

      • Evan L. Riddle, Annette E. Fleckenstein, Glen R. Hanson
      Pages 169-177

    2. Development of the Dopamine Transporter Selective RTI-336 as a Pharmacotherapy for Cocaine Abuse

      • F. Ivy Carroll, James L. Howard, Leonard L. Howell, Barbara S. Fox, Michael J. Kuhar
      Pages 179-191

    3. Serotonin Transporters: Implications for Antidepressant Drug Development

      • Kellie J. White, Crystal C. Walline, Eric L. Barker
      Pages 193-215

    4. Recent Advances for the Treatment of Cocaine Abuse: Central Nervous System Immunopharmacotherapy

      • Tobin J. Dickerson, Kim D. Janda
      Pages 217-229

    5. κ Opioids as Potential Treatments for Stimulant Dependence

      • Thomas E. Prisinzano, Kevin Tidgewell, Wayne W. Harding
      Pages 231-245

    6. Regulation of Monoamine Transporters: Influence of Psychostimulants and Therapeutic Antidepressants

      • Lankupalle D. Jayanthi, Sammanda Ramamoorthy
      Pages 247-264

    7. Hallucinogen Actions on 5-HT Receptors Reveal Distinct Mechanisms of Activation and Signaling by G Protein-Coupled Receptors

      • Harel Weinstein
      Pages 265-286

    8. Recognition of Psychostimulants, Antidepressants, and Other Inhibitors of Synaptic Neurotransmitter Uptake by the Plasma Membrane Monoamine Transporters

      • Christopher K. Surratt, Okechukwu T. Ukairo, Suneetha Ramanujapuram
      Pages 287-309

    9. Dual Dopamine/Serotonin Releasers as Potential Medications for Stimulant and Alcohol Addictions

      • Richard B. Rothman, Bruce E. Blough, Michael H. Baumann
      Pages 311-326
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Keywords

About this book

Drug Addiction: From Basic Research to Therapy provides a comprehensive overview of physiological, biochemical, and genetic pathways underlying drug addiction, and resultant efforts to develop novel treatment strategies dealing with drug addiction and other CNS disorders where the neurophysiological processes overlap, such as treatment of pain. Based on the AAPS-NIDA Frontiers in Science Symposium “Drug Addiction: From Basic Research to Therapies,” this volume, representing focuses on the translation of fundamental addiction research to a variety of treatments, bringing together scientists with widely ranging expertise in synthetic and computational chemistry, molecular biology, genetics, and neuroscience with researchers in drug discovery and development, drug targeting, and quantitative therapeutics.

Reviews

From the reviews:

"This book grew out of a symposium entitled ‘Frontiers in Science: Drug Addiction–From Basic Research to Therapies’ held at the end of 2004. … The book is composed of 44 chapters, all concerned with basic science research relevant to drug dependence. … even for basic scientists this book is best approached as one where at most a few chapters may be of interest to any researcher … in drug addiction." (Jason White, Drug And Alcohol Review, Vol. 28, July, 2009)

Editors and Affiliations

  • National Institute on Drug Abuse, Bethesda, USA

    Rao S. Rapaka

  • College of Medicine and Public Health, Ohio State University, Columbus, USA

    Wolfgang Sadée

Bibliographic Information

  • Book Title: Drug Addiction

  • Book Subtitle: From Basic Research to Therapy

  • Editors: Rao S. Rapaka, Wolfgang Sadée

  • DOI: https://doi.org/10.1007/978-0-387-76678-2

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag New York 2008

  • Hardcover ISBN: 978-0-387-76677-5Published: 07 July 2008

  • Softcover ISBN: 978-1-4419-2632-6Published: 25 November 2010

  • eBook ISBN: 978-0-387-76678-2Published: 19 June 2008

  • Edition Number: 1

  • Number of Pages: XXIII, 782

  • Number of Illustrations: 196 b/w illustrations, 1 illustrations in colour

  • Topics: Pharmacology/Toxicology

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