Editors:
- This is the first book to deal with the theoretical aspects and with the clinical applications of pharmacokinetic and pharmacodynamic modeling in the field of antimicrobial drug therapy
- Numerous subjects will be discussed including basic pharmacodynamic theory, pharmacokinetic complexities, and the use of in vitro and animal PK/PD models.
- Includes supplementary material: sn.pub/extras
Buy it now
Buying options
Tax calculation will be finalised at checkout
Other ways to access
This is a preview of subscription content, log in via an institution to check for access.
Table of contents (17 chapters)
-
Front Matter
-
Basic Concepts and Principles
-
Front Matter
-
-
Clinically Oriented Chapters
-
Front Matter
-
About this book
Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development.
The book will be designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.
Reviews
From the reviews:
“The book’s first half can function as an advanced textbook and support learning these concepts and principles. The level and presentation are appropriate for learners who already have a reasonable grasp of general pharmacokinetics and pharmacodynamics, such as advanced graduate students, medical students, or pharmacy students. … The second half applies these principles to an in-depth analysis of pharmacokinetics/pharmacodynamics for classes of antimicrobial drugs. This treatment can enhance the understanding and the application of these concepts for even experienced practitioners.” (Gregory Reed, Doody’s Book Reviews, June, 2014)Editors and Affiliations
-
Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, USA
Alexander A. Vinks
-
Dept. Pharmaceutics, University of Florida, Gainesville College of Pharmacy, Gainesville, USA
Hartmut Derendorf
-
Dept. of Medical Microbiology, Radboudumc, Radboud University Nijmegen, Nijmegen, The Netherlands
Johan W. Mouton
Bibliographic Information
Book Title: Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics
Editors: Alexander A. Vinks, Hartmut Derendorf, Johan W. Mouton
DOI: https://doi.org/10.1007/978-0-387-75613-4
Publisher: Springer New York, NY
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Science+Business Media New York 2014
Hardcover ISBN: 978-0-387-75612-7
Softcover ISBN: 978-1-4939-5081-2
eBook ISBN: 978-0-387-75613-4
Edition Number: 1
Number of Pages: IX, 466
Number of Illustrations: 98 b/w illustrations, 12 illustrations in colour
Topics: Infectious Diseases, Pharmacology/Toxicology, Immunology, Medical Microbiology, Public Health