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Cortical Deficits in Schizophrenia

From Genes to Function

  • Book
  • © 2008

Overview

Editors:
  1. Patricio O'Donnell

    1. University of Maryland School of Medicine, Baltimore, USA

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  • Presents the latest research on how genetic predisposition can produce schizophrenia’s pathophysiological outcomes

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Schizophrenia Genes: Searching for Common Features, Functions, and Mechanisms

    • Paul J. Harrison
    Pages 1-16

  3. Towards a Molecular Classification of Illness: Effects of Schizophrenia Susceptibility Loci on Clinical Symptoms and Cognitive Function

    • Anil K. Malhotra, Pamela DeRosse, Katherine E. Burdick
    Pages 17-28

  4. Homer: A Genetic Factor in Schizophrenia?

    • Karen K. Szumlinski, Todd E. Kippin
    Pages 29-72

  5. Neuregulin-erbB Signaling and the Pathogenesis of Schizophrenia

    • Christine Roy, Gabriel Corfas
    Pages 73-96

  6. Nicotinic Cholinergic Cortical Dysfunction in Schizophrenia

    • Jason R. Tregellas, Robert Freedman
    Pages 97-111

  7. A Role for Glutamate Receptors, Transporters, and Interacting Proteins in Cortical Dysfunction in Schizophrenia

    • Deborah Bauer, Robert E. McCullumsmith, James H. Meador-Woodruff
    Pages 113-147

  8. Cortical Circuit Dysfunction in the NMDA Receptor Hypofunction Model for the Psychosis of Schizophrenia

    • Robert Greene
    Pages 149-155

  9. Alterations in Hippocampal Function in Schizophrenia: its Genetic Associations and Systems Implications

    • Subroto Ghose, Carol A. Tamminga
    Pages 157-190

  10. Identifying Novel Target Genes in Psychotic Disorder Network Association Analyses

    • Francine M. Benes, Benjamin Lim, David Matzilevich, John Walsh
    Pages 191-203

  11. Alterations in Cortical GABA Neurotransmission in Schizophrenia: Causes and Consequences

    • David A. Lewis, Takanori Hashimoto, Jaime G. Maldonado-Aviles, Harvey Morris
    Pages 205-218

  12. Increased Cortical Excitability as a Critical Element in Schizophrenia Pathophysiology

    • Patricio O'Donnell
    Pages 219-236

  13. Back Matter

    Pages 237-239
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Keywords

About this book

The genetics of schizophrenia have taken the driver seat in the research - lated to this disorder in recent years. For a long time, it had been known that sharing genes with someone affected with schizophrenia conferred a 50% chance of acquiring the disease. Although this is fifty times the incidence in the normal population, it was evident that genes could not explain all factors involved. At best, one could think of a combination of gene traits conferring predisposition for the disease. Now, it is evident that although there are no genes that individually confer a strong liability, several candidate gene alleles do confer some risk, and perhaps a combination of genes could cause the emergence of symptoms in this multi-faceted psychiatric condition. As the research on predisposing genes soars, it is becoming clear that we need to be able to identify cellular processes the genes control and to provide pat- physiological scenarios that could link those cellular phenomena with sy- toms. In this book, we have chosen to elaborate on that link. The contributions to this book have been requested to reflect the current state of the connection between schizophrenia genetics and pathophysiology. The book opens with a chapter by Paul Harrison highlighting the several convergence points among the diverse schizophrenia-related genes.

Reviews

From the reviews:

"Cortical Deficits in Schizophrenia: From Genes to Function is an important contribution to the literature on schizophrenic syndrome analysis. It also can serve as an excellent model of productive interdisciplinary collaboration. Clinical as well as basic scientific specialists from a very wide variety of disciplines who share a common interest in schizophrenic syndrome analysis will find much new information in this work that is insightful, original, and exceptionally well integrated." (James A. Moses, PsycCRITIQUES, Vol. 34 (3), August, 2008)

Editors and Affiliations

  • University of Maryland School of Medicine, Baltimore, USA

    Patricio O'Donnell

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