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Cannabinoids and the Brain

  • Book
  • © 2008

Overview

Editors:
  1. Attila Köfalvi

    1. Center for Neurosciences of Coimbra, University of Coimbra, Coimbra, Portugal

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  • Though there are books on cannabinoids available on the market, they do not thoroughly deal with the neuroscience and therapeutic potential of cannabinoids

  • Presents the latest research in the growing endocannabinoid research field

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xv
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  2. Molecular Biology, Pharmacology, Anatomy, and Physiology of the Endocannabinoid and Related Lipidergic Signaling Systems in the Brain

    1. An Historical Introduction to the Endocannabinoid and Endovanilloid Systems

      • Istvan Nagy, John P. M. White, Cleoper C. Paule, Attila Köfalvi
      Pages 3-13

    2. Biosynthesis of Anandamide and 2-Arachidonoylglycerol

      • Takayuki Sugiura
      Pages 15-30

    3. Removal of Endocannabinoids by the Body: Mechanisms and Therapeutic Possibilities

      • Christopher J. Fowler, Lina Thors
      Pages 31-46

    4. Other Cannabimimetic Lipid Signaling Molecules

      • Heather B. Bradshaw
      Pages 47-58

    5. CB1 Cannabinoid Receptors: Molecular Biology, Second Messenger Coupling and Polarized Trafficking in Neurons

      • Andrew J. Irving, Neil A. McDonald, Tibor Harkany
      Pages 59-73

    6. CB2 Cannabinoid Receptors: Molecular, Signaling, and Trafficking Properties

      • Paul L. Prather
      Pages 75-90

    7. CB1 and CB2 Receptor Pharmacology

      • Roger G. Pertwee
      Pages 91-99

    8. Functional Molecular Biology of the TRPV1 Ion Channel

      • Istvan Nagy, John P. M. White, Cleoper C. Paule, Mervyn Maze, Laszlo Urban
      Pages 101-130

    9. Alternative Interacting Sites and Novel Receptors for Cannabinoid Ligands

      • Attila Köfalvi
      Pages 131-160

    10. Anatomical Distribution of Receptors, Ligands and Enzymes in the Brain and in the Spinal Cord: Circuitries and Neurochemistry

      • Giovanni Marsicano, Rohini Kuner
      Pages 161-201

    11. Endocannabinoids at the Synapse: Retrograde Signaling and Presynaptic Plasticity in the Brain

      • Gregory L. Gerdeman
      Pages 203-236

    12. Endocannabinoid Functions in Neurogenesis, Neuronal Migration, and Specification

      • Tibor Harkany, Manuel Guzmán, Yasmin L. Hurd
      Pages 237-256

  3. The Endocannabinoid System in Clinical Neuroscience and Experimental Neuropsychiatry

    1. Cannabinoids in the Management of Nausea and Vomiting

      • Linda A. Parker, Cheryl L. Limebeer
      Pages 259-276

    2. Endocannabinoids in Energy Homeostasis and Metabolic Disorders

      • Isabel Matias, Vincenzo Di Marzo, Attila Köfalvi
      Pages 277-316

    3. Cannabinoids and Neuroprotection

      • Veronica A. Campbell, Eric J. Downer
      Pages 317-329

    4. Neuroinflammation and the Glial Endocannabinoid System

      • Cristina Benito, Rosa María Tolón, Estefanía Núñez, María Ruth Pazos, Julián Romero
      Pages 331-359

    5. Targeting Cannabinoid Receptors in Brain Tumors

      • Guillermo Velasco, Arkaitz Carracedo, Cristina Blázquez, Mar Lorente, Tania Aguado, Cristina Sánchez et al.
      Pages 361-374

    6. Cannabinoids for the Control of multiple Sclerosis

      • Gareth Pryce, Sam J. Jackson, David Baker
      Pages 375-394

    7. Endocannabinoids in Alzheimer's Disease

      • María L. de Ceballos
      Pages 395-405
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Keywords

About this book

Endocannabinoids control most of the body functions, and in the brain, they modulate neurotransmission, synaptic plasticity, confer neuroprotection, control metabolism, neuro- and neuritogenesis, survival, cognitive and motor functions as well as a plethora of other higher-order brain functions. Their fruitful therapeutic potential is recognized by cannabinoid researchers and pharmaceutical companies, respectively.

The aim of this book is to help clinicians, neuroscientists, as well as students, understand the significance of the endocannabinoid system. This book, however, also will be very useful to those who already feel comfortable with the neuroscience of endocannabinoids. The book will introduce the reader to the “up-to-date” neurobiology of endocannabinoids and related systems, and will detail their pathophysiological role and therapeutic potential. Authors involved in clinical investigations present results of recent clinical trials, and the development of new therapeutic strategies and medicines.

Editors and Affiliations

  • Center for Neurosciences of Coimbra, University of Coimbra, Coimbra, Portugal

    Attila Köfalvi

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