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Central Nervous System Diseases and Inflammation

  • Book
  • © 2008

Overview

Editors:
  1. Thomas E. Lane

    1. Center for Immunology Department of Molecular Biology & Biochemistry, University of California, Irvine, USA

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  2. Monica Carson

    1. Department of Biomedical Sciences, University of California, Riverside, USA

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  3. Conni Bergmann

    1. USC Keck School of Medicine Neurology and Pathology, University of Southern California, Los Angeles, USA

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  4. Tony Wyss-Coray

    1. Department of Neurology, School of Medicine, Stanford, USA
      Stanford University School of Medicine, Stanford, USA

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  • Editors and contributors are top names in the field

  • Topical approach and organization of the volume provides a succinct overview of a specific subject relating to interrelated topics pertaining to neurology, immunology, and disease

  • Includes supplementary material: sn.pub/extras

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-viii
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  2. Microglia: A CNS-Specific Tissue Macrophage

    • Shweta S. Puntambekar, Jonathan M. Doose, Monica J. Carson
    Pages 1-12

  3. Mechanisms of Microglial Activation by Amyloid Precursor Protein and its Proteolytic Fragments

    • S. A. Austin, C. K. Combs
    Pages 13-32

  4. Pericytes

    • Martin Krüger, Ingo Bechmann
    Pages 33-43

  5. Imaging Microglia in the Central Nervous System: Past, Present and Future

    • Dimitrios Davalos, Katerina Akassoglou
    Pages 45-57

  6. Cytokines in CNS Inflammation and Disease

    • Malú G. Tansey, Tony Wyss-Coray
    Pages 59-106

  7. Arachidonic Acid Metabolites: Function in Neurotoxicity and Inflammation in the Central Nervous System

    • K. Andreasson, T. J. Montine
    Pages 107-129

  8. Pattern Recognition Receptors in CNS Disease

    • Pamela A. Carpentier, D'Anne S. Duncan, Stephen D. Miller
    Pages 131-152

  9. Central Nervous System Diseases and Inflammation

    • Andrea J. Tenner, Karntipa Pisalyaput
    Pages 153-174

  10. Chemokines and Autoimmune Demyelination

    • Michaela Fux, Jason Millward, Trevor Owens
    Pages 175-201

  11. Chemokine Actions in the CNS: Insights from Transgenic Mice

    • Marcus Müller, Iain L. Campbell
    Pages 203-219

  12. Chemokines and Spinal Cord Injury

    • Maya N. Hatch, Hans S. Keirstead
    Pages 221-233

  13. The Usual Suspects: Chemokines and Microbial Infection of the Central Nervous System

    • Michelle J. Hickey, Linda N. Stiles, Chris S. Schaumburg
    Pages 235-261

  14. CNS Dendritic Cells in Inflammation and Disease

    • Samantha L. Bailey, Stephen D. Miller
    Pages 263-275

  15. MHC Class I Expression and CD8 T Cell Function: Towards the Cell Biology of T-APC Interactions in the Infected Brain

    • Cornelia Bergmann, Pedro Lowenstein
    Pages 277-306

  16. Back Matter

    Pages 307-313
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Keywords

About this book

Up until approximately 20 years ago, the idea that the central nervous system (CNS) and components of the immune system were dynamically interactive was considered impossible (or at least highly unlikely) as the CNS was judged an immunosuppressive environment based upon experimental evidence highlighting the survival of tissue grafts within the brain. Additional evidence supporting this viewpoint included (i) the presence of the blood–brain barrier (BBB) which p- vides a physical and physiological obstruction that is difficult for cells and mac- molecules to cross, (ii) the relative absence of MHC class I and II expression on CNS cells like astrocytes and neurons, and (iii) lack of abundant antigen presenting cells (APC) which are required for the generation of an adaptive immune response. However, in spite of these obstacles, it is now well-accepted that the CNS is r- tinely subject to immune surveillance under both normal as well as diseased con- tions. Indeed, activated cells of the immune system such as T and B lymphocytes and monocyte/macrophages readily infiltrate and accumulate within the CNS f- lowing microbial infection, injury, or upon development of autoimmune responses directed toward resident antigens of the CNS.

Reviews

From the reviews:

"The involvement of the immune system in central nervous system diseases is highlighted in this book, which details important advances in the understanding of certain aspects of neuroinflammation. … This is clearly appropriate for clinicians and researchers who are interested in neuroinflammation in the central nervous system. It also can be a valuable research guide for students who are interested in learning some basics on this topic. … It makes worthwhile contributions to this area." (Christine Maria Rohowsky-Kochan, Doody’s Review Service, September, 2008)

Editors and Affiliations

  • Center for Immunology Department of Molecular Biology & Biochemistry, University of California, Irvine, USA

    Thomas E. Lane

  • Department of Biomedical Sciences, University of California, Riverside, USA

    Monica Carson

  • USC Keck School of Medicine Neurology and Pathology, University of Southern California, Los Angeles, USA

    Conni Bergmann

  • Department of Neurology, School of Medicine, Stanford, USA

    Tony Wyss-Coray

  • Stanford University School of Medicine, Stanford, USA

    Tony Wyss-Coray

Bibliographic Information

  • Book Title: Central Nervous System Diseases and Inflammation

  • Editors: Thomas E. Lane, Monica Carson, Conni Bergmann, Tony Wyss-Coray

  • DOI: https://doi.org/10.1007/978-0-387-73894-9

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag US 2008

  • Hardcover ISBN: 978-0-387-73893-2Published: 14 December 2007

  • Softcover ISBN: 978-1-4419-4480-1Published: 19 November 2010

  • eBook ISBN: 978-0-387-73894-9Published: 24 December 2007

  • Edition Number: 1

  • Number of Pages: VIII, 318

  • Number of Illustrations: 1 b/w illustrations, 9 illustrations in colour

  • Topics: Immunology, Neurosciences, Virology, Microbiology, Pharmacology/Toxicology

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