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  • Book
  • © 2009

Functional Nucleic Acids for Analytical Applications

Editors:

  • First in the rapidly emerging field on analytical applications for nucleic acids
  • With interdisciplinary approach, a valuable tool for researchers in chemistry, biology, and engineering
  • One of the first books in the series Integrated Microanalytical Systems, recently renamed Integrated Analytical Systems, edited by R. Potyrailo

Part of the book series: Integrated Analytical Systems (ANASYS)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-viii
  2. Overview of Functional Nucleic Acids and Their Analytical Applications

    1. Introductory Remarks

      • Yi Lu, Yingfu Li
      Pages 3-9
    2. Natural Functional Nucleic Acids: Ribozymes and Riboswitches

      • Renaud Tremblay, Jérôme Mulhbacher, Simon Blouin, J. Carlos Penedo, Daniel A. Lafontaine
      Pages 11-46
  3. Functional Nucleic Acid Sensors Based on Different Transduction Principles

    1. Fluorescent Aptamer Sensors

      • Hui William Chen, Youngmi Kim, Ling Meng, Prabodhika Mallikaratchy, Jennifer Martin, Zhiwen Tang et al.
      Pages 111-130
    2. Fluorescent Ribozyme and Deoxyribozyme Sensors

      • William Chiuman, Yingfu Li
      Pages 131-153
    3. Electrochemical Approaches to Aptamer-Based Sensing

      • Yi Xiao, Kevin W. Plaxco
      Pages 179-197
    4. Amplified DNA Biosensors

      • Itamar Willner, Bella Shlyahovsky, Bilha Willner, Maya Zayats
      Pages 199-252
  4. Other Emerging Analytical Applications

    1. Aptamers in Affinity Separations:Capillary Electrophoresis

      • Jeffrey W. Guthrie, Yuanhua Shao, X. Chris Le
      Pages 255-270
    2. Aptamers in Affinity Separations: Stationary Separation

      • Corinne Ravelet, Eric Peyrin
      Pages 271-286
    3. Aptamer Microarrays

      • Heather Angel Syrett, James R. Collett, Andrew D. Ellington
      Pages 287-308
    4. The Use of Functional Nucleic Acids in Solid-Phase Fluorimetric Assays

      • Nicholas Rupcich, Razvan Nutiu, Yutu Shen, Yingfu Li, John D. Brennan
      Pages 309-342
    5. Functional Nucleic Acid Sensors as Screening Tools

      • Andrea Rentmeister, Michael Famulok
      Pages 343-354
    6. Nucleic Acids for Computation

      • Joanne Macdonald, Milan N. Stojanovic
      Pages 355-375
    7. DNAzymes in DNA Nanomachines and DNA Analysis

      • Yu He, Ye Tian, Yi Chen, Chengde Mao
      Pages 377-388
  5. Back Matter

    Pages 389-395

About this book

Nature has long used nucleic acid aptamers and enzymes for regulatory activities, such as the recently discovered “riboswitches” involved in gene expression. The existence of a large array of natural and artificial functional nucleic acids has generated tremendous enthusiasm and new opportunities for molecular scientists from diverse disciplines to devise new concepts and real applications that take advantage of those nucleic acids for sensing and other analytical applications. This book provides a timely and comprehensive overview of recent advances in the field, from leading experts in biology, chemistry, and engineering. A variety of topics are covered, from fundamentals of functional nucleic acids, to their applications as sensors, to nanotechnologies; as well as integration of functional nucleic acids into practical analytical systems.

Reviews

From the reviews:

"This book consists of 15 chapters contributed by experts in the field of functional nucleic acids, mostly in the area of specific analytical applications of nucleic acids … . this book affords a comprehensive collection of clearly presented, up-to-date reviews that broadly cover the numerous applications of functional nucleic acids. … The chapters are of high quality … that will be useful to newcomers entering the field of functional nucleic acids and to those interested in exploring other applications complementary to their own niches." (Jennifer S. Brodbelt, Journal of the American Chemical Society, Vol. 131 (32), 2009)

“The book is well structured and combines 15 insightful reviews written by many leading experts. … Functional Nucleic Acids for Analytical Applications is a comprehensive and well written book. With its excellent review of recent progress and critical outlook of future directions it will be very valuable for researchers wishing to explore the unique properties of FNAs for different applications in analytical and bioanalytical chemistry.”­­­ (Xiaohong Fang, Analytical and Bioanalytical Chemistry, Vol. 398, June, 2010)

Editors and Affiliations

  • Department of Biochemistry and Biomedical Sciences, McMaster University Hamilton, Ontario, Canada

    Li Yingfu

  • Department of Chemistry, University of Illinois at Urbana-Champaign Urbana, Illinois, USA

    Lu Yi

Bibliographic Information

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access