Pediatric Inflammatory Bowel Disease

1. Front Matter

   Pages I-XXXIII

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2. Etiology and Pathogenesis

   1. Front Matter

      Pages 1-1

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   2. Genetics of Inflammatory Bowel Diseases

      • Nancy McGreal, Judy H. Cho

      Pages 3-14

   3. Gut Immunity and Inflammatory Bowel Disease

      • William A. Faubion, Claudio Fiocchi

      Pages 15-29

   4. Cytokines and Inflammatory Bowel Disease

      • Edwin F. de Zoeten, Ivan J. Fuss

      Pages 31-41

3. Epidemiology and Clinical Features

   1. Front Matter

      Pages 43-43

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   2. Epidemiology of Pediatric Inflammatory Bowel Disease

      • Shehzad Saeed, Subra Kugathasan

      Pages 45-60

   3. Early Onset Inflammatory Bowel Disease- Epidemiology and Clinical Features

      • Melvin B. Heyman, Neera Gupta

      Pages 61-65

   4. The Natural History of Pediatric Crohn Disease

      • James Markowitz

      Pages 67-74

   5. Natural History of Pediatric Ulcerative Colitis

      • Jeffrey S. Hyams

      Pages 75-81

   6. Natural History of Pediatric Indeterminate Colitis

      • Michael D. Kappelman, Richard J. Grand

      Pages 83-90

   7. Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease

      • Shervin Rabizadeh, Maria Oliva-Hemker

      Pages 91-101

   8. Growth Impairment in Pediatric Inflammatory Bowel Disease

      • Thomas D. Walters, Anne M. Griffiths

      Pages 103-117

   9. Skeletal Health in Pediatric Inflammatory Bowel Disease

      • Francisco Sylvester

      Pages 119-132

   10. Puberty and Pediatric-Onset Inflammatory Bowel Disease

       • Barbara S. Kirschner, Barry H. Rich

       Pages 133-142

   11. Classification of Pediatric Inflammatory Bowel Disease

       • Athos Bousvaros

       Pages 143-155

4. Diagnosis

   1. Front Matter

      Pages 157-157

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   2. The History and Physical Exam in Pediatric Inflammatory Bowel Disease

      • Cheryl Blank, David J. Keljo

      Pages 159-163

   3. Differential Diagnosis of Pediatric Inflammatory Bowel Disease

      • Thierry Lamireau

      Pages 165-178

   4. Laboratory Evaluation of Pediatric Inflammatory Bowel Disease

      • Jennifer Strople, Benjamin D. Gold

      Pages 179-191

Pediatric Inflammatory Bowel Diseases (IBD) are the most common and most significant chronic disorders in Pediatric Gastroenterology. The onset of Crohn disease and ulcerative colitis in the first two decades of life presents a number of diagnostic and therapeutic challenges that are unique to pediatric patients. Although the studies available for pediatric diagnosis have improved dramatically in the past three decades, the improvement in technology alone cannot account for the increased frequency of IBD recognized in early childhood. While therapy for older patients has improved dramatically with the use of immunomodulators and the development of exciting biologic strategies, rarely if ever have comprehensive studies of the pharmacokinetics, safety and efficacy of any of the IBD medications been performed in pediatric patients. A number of excellent medications are not available in liquid preparations that can be swallowed by children, and others, such as timed-release formulations, are developed for delivery to an adult gastrointestinal tract. It is unfortunate that the care we provide to children is often an extrapolation of what is known about and available for adults with IBD. Pediatric patients with IBD face a number of unique challenges. The onset of disease before puberty can be devastating. Growth failure is a particularly difficult problem with potentially permanent consequences. Much of the pediatric specific research has focused on the role of nutritional therapy to treat growth failure and induce remission.

• Bone density
• Genetics
• Nutrition
• Therapeutics
• endoscopy

From the reviews:

"This is a thorough discussion of pediatric inflammatory bowel disease … . written for pediatric gastroenterologists, the book is a useful reference for any person caring for pediatric inflammatory bowel disease patients, including residents, general pediatricians, adult gastroenterologists, and internists. … an outstanding review of pediatric IBD for anyone involved in the care of patients with this disorder. Topics … are discussed well in an easy-to-read manner with numerous references. The book is printed on high-quality, glossy paper allowing excellent reproduction of photographs … ." (Essam Imseis, Doody’s Review Service, August, 2008)

"This book provides a thorough update of the pathophysiology and clinical features of gastrointestinal disease in children … . Pediatric Inflammatory Bowel Disease will be an important resource primarily for pediatric gastroenterologists. However, all physicians who care for children with inflammatory bowel disease will find that it serves as a model for organizing clinicians to collectively advance the knowledge of the disorder through common clinical practice and participation in future research protocols." (Kathleen J. Motil, The New England Journal of Medicine, September, 2008)

• Attending Physician, Division of GI Hepatology and Nutrition, Director Endoscopy Suite, The Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, USA

  Petar Mamula

• Attending Physician, Children’s Center for Digestive Health, Greenville Hospital System University Medical Center, University of South Carolina School of Medicine, Greenville, USA

  Jonathan E. Markowitz

• Attending Physician and Director, Inflammatory Bowel Disease Center Division of GI, Hepatology and Nutrition. The Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, USA

  Robert N. Baldassano

Policies and ethics