Acute Neuronal Injury

1. Front Matter

   Pages i-xi

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2. Caspase-Independent Programmed Cell Death: General Considerations

   1. Front Matter

      Pages 1-1

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   2. Introduction

      • Denson G. Fujikawa

      Pages 1-6

   3. Caspase-Independent Cell Death Mechanisms in Simple Animal Models

      • Matthias Rieckher, Nektarios Tavernarakis

      Pages 9-33

   4. Programmed Necrosis: A “New” Cell Death Outcome for Injured Adult Neurons?

      • Slavica Krantic, Santos A. Susin

      Pages 35-66

   5. Age-Dependence of Neuronal Apoptosis and of Caspase Activation

      • Denson G. Fujikawa

      Pages 67-77

   6. Excitotoxic Programmed Cell Death Involves Caspase-Independent Mechanisms

      • Ho Chul Kang, Ted M. Dawson, Valina L. Dawson

      Pages 79-88

3. Focal Cerebral Ischemia

   1. Front Matter

      Pages 90-90

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   2. Significant Role of Apoptosis-Inducing Factor (AIF) for Brain Damage Following Focal Cerebral Ischemia

      • Nikolaus Plesnila, Carsten Culmsee

      Pages 91-101

   3. The Role of Poly(ADP-Ribose) Polymerase-1 (PARP-1) Activation in Focal Cerebral Ischemia

      • Giuseppe Faraco, Alberto Chiarugi

      Pages 103-118

4. Transient Global Ischemia

   1. Front Matter

      Pages 120-120

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   2. Transient Global Cerebral Ischemia Produces Morphologically Necrotic, Not Apoptotic Neurons

      • Frederick Colbourne, Roland N. Auer

      Pages 121-130

   3. Apoptosis-Inducing Factor Translocation to Nuclei After Transient Global Ischemia

      • Can Liu, Armando P. Signore, Guodong Cao, Jun Chen

      Pages 131-144

   4. Role of µ-Calpain I and Lysosomal Cathepsins in Hippocampal Neuronal Necrosis After Transient Global Ischemia in Primates

      • Anton B. Tonchev, Tetsumori Yamashima

      Pages 145-153

5. Traumatic Central Nervous System (CNS) Injury

   1. Front Matter

      Pages 156-156

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   2. Mitochondrial Damage in Traumatic CNS Injury

      • Laurie M. Davis, Patrick G. Sullivan

      Pages 157-168

   3. Programmed Neuronal Cell Death Mechanisms in CNS Injury

      • Bogdan A. Stoica, Alan I. Faden

      Pages 169-200

6. Hypoglycemic Neuronal Death

   1. Front Matter

      Pages 202-202

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   2. Hypoglycemic Brain Damage

      • Roland N. Auer

      Pages 203-210

   3. Hypoglycemic Neuronal Death

      • Raymond A. Swanson, Sang Won Suh

      Pages 211-228

This book is the result of a convergence of scientific information regarding mechanisms that produce acute nerve cell death in the brain. Although seemingly disparate, stroke, brain and spinal cord trauma, coma from a low serum glucose concentration (hypoglycemia), and prolonged epileptic seizures have in common the inciting factor of excitotoxicity, the activation of a specific subtype of glutamate receptor by an elevated extracellular glutamate concentration that results in an excessive influx of calcium into nerve cells. The high calcium concentration in nerve cells activates several enzymes that are responsible for degradation of cytoplasmic proteins and cleavage of nuclear DNA, resulting in nerve cell death. The high calcium concentration also interferes with mitochondrial respiration, with the resultant production of free radicals that damage cellular membranes and nuclear DNA. Understanding the biochemical pathways that produce nerve cell death is the first step toward devising an effective neuroprotective strategy, the ultimate goal.

Acute Neuronal Injury will be useful to neuroscientists and general cell biologists interested in cell death. The book will also be helpful to clinically oriented neuroscientists, including neurologists, neurosurgeons and psychiatrists.

About the Editor:

Dr. Denson Fujikawa is an Adjunct Professor of Neurology at the David Geffen School of Medicine at UCLA, a member of the Brain Research Institute at UCLA and a Sta

ff Neurologist at the Department of Veterans Affairs Greater Los Angeles Healthcare System. His interest in mechanisms of nerve cell death in the brain began during a two-year epilepsy research fellowship with Dr. Claude Wasterlain, from 1981 to 1983. He is a Fellow of the American Academy of Neurology and is a member of the American Epilepsy Society, American Neurological Association, International Society for Cerebral Blood Flow and Metabolism, and the Society for Neuroscience.

• DNA
• Flow
• Nervous System
• Neurology
• Neuroscience
• apoptosis
• caspase-independent mechanisms
• excitotoxicity
• necrosis
• neurons
• programmed cell death

“This is an outstanding book concerning the molecular and cellular mechanisms of trauma and ischemia in the mammalian brain. … I recommend his book to neurophysiologists, neurologists, and neurosurgeons.” (Joseph J. Grenier, Amazon.com, September, 2015)

• Healthcare System, VA Greater Los Angeles, North Hills, U.S.A.

  Denson G. Fujikawa

Dr. Denson Fujikawa is an Adjunct Professor of Neurology at the David Geffen School of Medicine at UCLA, a member of the Brain Research Institute at UCLA and a Staff Neurologist at the Department of Veterans Affairs Greater Los Angeles Healthcare System. His interest in mechanisms of nerve cell death in the brain began during a two-year epilepsy research fellowship with Dr. Claude Wasterlain, from 1981 to 1983. He is a Fellow of the American Academy of Neurology and is a member of the American Epilepsy Society, American Neurological Association, International Society for Cerebral Blood Flow and Metabolism and the Society for Neuroscience.

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