Atherosclerosis and Oxidant Stress: A New Perspective

1. Front Matter

   Pages i-x

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2. The Pathogenesis of Atherosclerosis and Plaque Instability

   • James S. Forrester

   Pages 1-10

3. Epidemiological Studies on Atherosclerosis: The Role of the Mediterranean Diet in the Prevention of Cardiovascular Disease

   • Edgar R. Miller III, Thomas P. Erlinger

   Pages 11-24

4. Interventional Trials of Antioxidants

   • Thomas S. Bowman, Shari S. Bassuk, J. Michael Gaziano

   Pages 25-50

5. Oxidative Stress in Arterial Hypertension: Oxidative Stress and Hypertension

   • Rhian M. Touyz, Ernesto L. Schiffrin

   Pages 51-78

6. Lipids, Oxidation, and Cardiovascular Disease

   • Myron D. Gross

   Pages 79-95

7. Nuclear Receptors in the Control of Lipid Metabolism

   • Shannon M. Reilly, Chih-Hao Lee

   Pages 96-122

8. Diabetes and Oxidant Stress

   • Alicia J. Jenkins, Michael A. Hill, Kevin G. Rowley

   Pages 123-158

9. Molecular Mechanisms of Environmental Atherogenesis

   • Kimberly P. Miller, Kenneth S. Ramos

   Pages 159-210

10. The Role of Glutathione Pathways in the Prevention of Atherosclerosis

    • Jordan L. Holtzman

    Pages 211-239

11. Back Matter

    Pages 241-247

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During the twentieth century we saw a veritable revolution in medicine. Some of the most notable advances have been in the elucidation of the risk factors for and treatment of cardio- and cerebral vascular disease. Identifying these factors through epidemiological studies has led to the development of guidelines for a healthy life style and therapies to control this major killer of the elderly. As a result of these efforts at the present time cardiovascular disease, rather than being the leading cause of death in the United States, has dropped to second behind cancer. Beginning with such seminal studies as the Seven Countries study and the Framingham program, these major advances have resulted from a collaboration among several disciplines, including epidemiology, clinical trials, cell biology, and basic biochemistry. The combined ? ndings from these disparate disciplines have served as the foundation for the institution of public health measures, such as smoking cessation campaigns and new dietary recommendations, as well as the development of medications to prevent disease through the control of such major risk factors as hypertension and hyperlipidemia. One of the major insights into the underlying cause of vascular injury is that it is initiated by oxidant injury to the vessel wall. The current volume is - ganized around the role of oxidant damage in this disease process.

• Mediterranean Diet
• cardiovascular
• cardiovascular disease
• cerebral vascular disease
• hypertension

• University of Minnesota, Minneapolis, USA

  Jordan L. Holtzman

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