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Actin-Binding Proteins and Disease

  • Book
  • © 2008

Overview

Editors:
  1. Cristobal G. Remedios

    1. Muscle Research Unit Bosch Institute, School of Medical Sciences, The University of Sydney, Sydney, Australia

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  2. Deepak Chhabra

    1. Discipline of Anatomy and Histology Bosch Institute, School of Medical Sciences, The University of Sydney, Sydney, Australia

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Will appeal to research scientists seeking contemporary overviews of actin-myosin interaction and actin-based regulation

Part of the book series: Protein Reviews (PRON, volume 8)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Actin

    1. Actin: An Overview of Its Structure and Function

      • Deepak Chhabra, Cristobal G. dos Remedios
      Pages 1-15

    2. Actin Genetic Diseases

      • John C. Sparrow, Nigel G. Laing
      Pages 16-36

    3. Actin-Binding Drugs: An Elegant Tool to Dissect Subcellular Processes in Endothelial and Cancer Cells

      • Filip Braet, Lilian Soon, Katrien Vekemans, Pall Thordarson, Ilan Spector
      Pages 37-49

    4. Autoantigenicity of Actin

      • Ian R. Mackay, Roberto Martinez-Neira, Senga Whittingham, Dan Nicolau, Ban-Hock Toh
      Pages 50-64

  3. Actin-Binding Proteins

    1. Overview: Actin-Binding Protein Function and Its Relation to Disease Pathology

      • Mira Krendel, Enrique M. De La Cruz
      Pages 65-82

    2. ADF/Cofilin, Actin Dynamics, and Disease

      • Michael T. Maloney, Andrew W. Kinley, Chi W. Pak, James R. Bamburg
      Pages 83-187

    3. Gelsolin and Disease

      • Leslie D. Burtnick, Robert C. Robinson
      Pages 188-199

    4. Profilin

      • Pierre D. J. Moens
      Pages 200-217

    5. The Roles of Thymosin β4 in Cell Migration and Cell-to-Cell Signaling in Disease

      • Joshua K. Au, Mira Krendel, Daniel Safer, Enrique M. De La Cruz
      Pages 218-228

  4. Actin-Binding Proteins

    1. Actin and Actin-Binding Proteins in Cancer Progression and Metastasis

      • Marleen Van Troys, Joël Vandekerckhove, Christophe Ampe
      Pages 229-277

    2. Diseases with Abnormal Actin and Actin-Binding Proteins in Leukocyte and Nonmuscle Cells

      • Hiroyuki Nunoi
      Pages 278-289

    3. The Role of PIP2 in Actin, Actin-Binding Proteins and Disease

      • C. G. dos Remedios, Neil J. Nosworthy
      Pages 290-297

    4. Intracellular Pathogens and the Actin Cytoskeleton

      • E. L. Bearer
      Pages 298-317

    5. Actin and Its Binding Proteins in Heart Failure

      • Maurizio Stefani, Masako Tsubakihara, Brett D. Hambly, Choon C. Liew, Paul D. Allen, Peter S. Macdonald et al.
      Pages 318-334

  5. Back Matter

    Pages 335-348
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Keywords

About this book

Actin is a ubiquitous protein present in high concentrations in virtually all cells. It's assembly and disassembly is modulated by more than 100 actin-binding proteins. These interactions are essential for a variety of important cellular processes including cell division, gene expression and motility.

There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders.

This volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole. Additionally, clinicians will be interested because the book explains the role of cytoskeletal proteins in various diseases, including cancer and immune system disorders.

Editors and Affiliations

  • Muscle Research Unit Bosch Institute, School of Medical Sciences, The University of Sydney, Sydney, Australia

    Cristobal G. Remedios

  • Discipline of Anatomy and Histology Bosch Institute, School of Medical Sciences, The University of Sydney, Sydney, Australia

    Deepak Chhabra

Bibliographic Information

  • Book Title: Actin-Binding Proteins and Disease

  • Editors: Cristobal G. Remedios, Deepak Chhabra

  • Series Title: Protein Reviews

  • DOI: https://doi.org/10.1007/978-0-387-71749-4

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag New York 2008

  • Hardcover ISBN: 978-0-387-71747-0Published: 26 November 2007

  • Softcover ISBN: 978-1-4419-2453-7Published: 19 November 2010

  • eBook ISBN: 978-0-387-71749-4Published: 08 January 2008

  • Edition Number: 1

  • Number of Pages: XIV, 348

  • Number of Illustrations: 30 b/w illustrations, 22 illustrations in colour

  • Topics: Cell Biology, Proteomics, Protein Science, Biochemistry, general

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