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Angiogenesis

An Integrative Approach from Science to Medicine

  • Book
  • © 2008

Overview

Editors:
  1. William D. Figg

    1. Center for Cancer Research, National Cancer Institute, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Judah Folkman

    1. Department of Surgery Harvard Medical School and Vascular Biology Program, Children's Hospital Boston, Boston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • A comprehensive, concise summary of tumor angiogenesis

  • An up-to-date and authoritative reference for the angiogenesis field as it relates to oncology

  • Includes supplementary material: sn.pub/extras

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Table of contents (48 chapters)

  1. Front Matter

    Pages i-xix
    Download chapter PDF

  2. Physiological & Pathological Angiogenesis: Biology of the Angiogenic Process

    1. History of Angiogenesis

      • Judah Folkman
      Pages 1-14

    2. Angiogenesis and Vascular Remodeling in Inflammation and Cancer: Biology and Architecture of the Vasculature

      • Donald M. McDonald
      Pages 17-33

    3. Endothelial Cell Activation

      • M. Luisa Iruela-Arispe
      Pages 35-43

    4. Pericytes, the Mural Cells of the Microvascular System

      • Gabriele Bergers
      Pages 45-53

    5. Matrix Metalloproteinases and Their Endogenous Inhibitors

      • Liliana Guedez, William G. Stetler-Stevenson
      Pages 55-62

    6. Integrins in Angiogenesis

      • Alireza S. Alavi, David A. Cheresh
      Pages 63-73

  3. Angiogenesis and Regulatory Proteins

    1. Fibroblast Growth Factor-2 in Angiogenesis

      • Marco Presta, Stefania Mitola, Patrizia Dell'Era, Daria Leali, Stefania Nicoli, Emanuela Moroni et al.
      Pages 77-88

    2. Vascular Permeability/Vascular Endothelial Growth Factor

      • Masabumi Shibuya
      Pages 89-98

    3. Platelet-Derived Growth Factor

      • Andrius Kazlauskas
      Pages 99-111

    4. Angiopoietins and Tie Receptors

      • Pipsa Saharinen, Lauri Eklund, Kari Alitalo
      Pages 113-120

    5. Basement Membrane Derived Inhibitors of Angiogenesis

      • Michael B. Duncan, Raghu Kalluri
      Pages 121-127

    6. Angiostatin and Endostatin: Angiogenesis Inhibitors in Blood and Stroma

      • Judah Folkman
      Pages 129-146

    7. Thrombospondins: Endogenous Inhibitors of Angiogenesis

      • Paul Bornstein
      Pages 147-158

  4. Molecular & Cellular Mechanisms of the Angiogenic Process

    1. Overview of Angiogenesis During Tumor Growth

      • Domenico Ribatti, Angelo Vacca
      Pages 161-168

    2. Hypoxic Regulation of Angiogenesis by HIF-1

      • Philip J. S. Charlesworth, Adrian L. Harris
      Pages 169-179

    3. Regulation of Angiogenesis by von Hippel Lindau Protein and HIF2

      • Donald P. Bottaro, Nelly Tan, W. Marston Linehan
      Pages 181-191

    4. Nitric Oxide in Tumor Angiogenesis

      • L. Morbidelli, S. Donnini, M. Ziche
      Pages 193-204

    5. VEGF Signal Tranduction in Angiogenesis

      • Harukiyo Kawamura, Xiujuan Li, Michael Welsh, Lena Claesson-Welsh
      Pages 205-216

    6. Delta-like Ligand 4/Notch Pathway in Tumor Angiogenesis

      • Gavin Thurston, Irene Noguera-Troise, Ivan B. Lobov, Christopher Daly, John S. Rudge, Nicholas W. Gale et al.
      Pages 217-224
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Keywords

About this book

Dr. Judah Folkman, “father of angiogenesis”, (1933-2008) was the Director of the Vascular Biology Program, Andrus Professor of Pediatric Surgery, and Professor of Cell Biology at Harvard University's Boston Children's Hospital. In the 1971 issue of The New England Journal of Medicine, he proposed the theory that tumor growth is angiogenesis dependent. This premise was the basis of this field of research and has become the focus of scientists worldwide. Because of Folkman's discovery and research, the possibilities of antiangiogenic and angiogenic therapy have broadened beyond cancer to many noncancerous diseases.

This book represents the first collection in a volume of which Dr. Folkman is co-editor. Dr. Folkman authored nearly 400 original papers and more than 100 book chapters.

Dr. William Figg is the chief of the Molecular and Clinical Pharmacology Program at the National Cancer Institute, National Institutes of Health. Over the past 15 years, his laboratory and clinic at the NCI have focused on the development of angiogenesis inhibitors. Dr. Figg has published more than 380 publications.

Reviews

From the reviews:

"Folkman ... assembled his final masterpiece in Angiogenesis, a book he coedited with William Figg. ... The text, written by well-known contributors to the field, is complemented by a large number of helpful schematics and photomicrographs. The references are extensive and encyclopedic. In summary, if I were to have a single textbook on this subject on my bookshelf, this book would have no competition. ... this will be the authoritative text on angiogenesis for many years to come." (Douglas W. Losordo, New England Journal of Medicine, Vol. 359 (23), December, 2008)

Editors and Affiliations

  • Center for Cancer Research, National Cancer Institute, Bethesda, USA

    William D. Figg

  • Department of Surgery Harvard Medical School and Vascular Biology Program, Children's Hospital Boston, Boston, USA

    Judah Folkman

Bibliographic Information

  • Book Title: Angiogenesis

  • Book Subtitle: An Integrative Approach from Science to Medicine

  • Editors: William D. Figg, Judah Folkman

  • DOI: https://doi.org/10.1007/978-0-387-71518-6

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag US 2008

  • Hardcover ISBN: 978-0-387-71517-9Published: 02 June 2008

  • Softcover ISBN: 978-1-4899-9668-8Published: 26 November 2014

  • eBook ISBN: 978-0-387-71518-6Published: 24 May 2008

  • Edition Number: 1

  • Number of Pages: XIX, 601

  • Topics: Oncology, Cancer Research, Molecular Medicine, Angiology

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