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Tumor-Induced Immune Suppression

Mechanisms and Therapeutic Reversal

  • Book
  • © 2008

Overview

Editors:
  1. Dmitry I. Gabrilovich

    1. H. Lee Moffitt Cancer Center, University of South Florida, Tampa, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Arthur A. Hurwitz

    1. Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Presents a comprehensive overview of different mechanisms of immune dysfunction
  • Discusses a number of new mechanisms that have never been discussed in a monogragraph report including: T-cell inhibitory molecules and regulatory tolergenic DCs
  • Focus on therapeutic correction of the observed abnormalities

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Table of contents (13 chapters)

  1. Front Matter

    Pages I-IX
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  2. Immune-Suppressive Mechanisms and Cancer: Understanding the Implications, Paradoxes, and Burning Questions

    • Arthur A. Hurwitz, Dmitry I. Gabrilovich
    Pages 1-5

  3. Mechanisms of Tumor-Associated T-Cell Tolerance

    • Adam J. Adler
    Pages 7-27

  4. Contribution of B7-H1/PD-1 Co-inhibitory Pathway to T-Cell Dysfunction in Cancer

    • Sheng Yao, Lieping Chen
    Pages 29-40

  5. Regulatory T Cells in Cancer

    • Silvia Piconese, Mario P. Colombo
    Pages 41-67

  6. Cancer-Induced Signaling Defects in Antitumor T Cells

    • Alan B. Frey
    Pages 69-100

  7. Immunobiology of Dendritic Cells in Cancer

    • Michael R. Shurin, Gurkamal S. Chatta
    Pages 101-130

  8. Macrophages and Tumor Development

    • Suzanne Ostrand-Rosenberg, Pratima Sinha
    Pages 131-155

  9. Myeloid-Derived Suppressor Cells in Cancer

    • Paolo Serafini, Vincenzo Bronte
    Pages 157-195

  10. Signaling Pathways in Antigen-Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance

    • Ildefonso Vicente-Suarez, Alejandro Villagra, Eduardo M. Sotomayor
    Pages 197-218

  11. Arginine Availability Regulates T-Cell Function in Cancer

    • Paulo C. Rodríguez, Augusto C. Ochoa
    Pages 219-233

  12. Protein–Glycan Interactions in the Regulation of Immune Cell Function in Cancer: Lessons from the Study of Galectins-1 and -3

    • Gabriel A. Rabinovich, Fu-Tong Liu
    Pages 235-258

  13. Role of Reactive Oxygen Species in T-Cell Defects in Cancer

    • Alex Corzo, Srinivas Nagaraj, Dmitry I. Gabrilovich
    Pages 259-280

  14. Tumor Stroma and the Antitumor Immune Response

    • Bin Zhang, Donald A. Rowley, Hans Schreiber
    Pages 281-294

  15. Back Matter

    Pages 295-301
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Keywords

About this book

There is now a pressing need to discuss the already described and newly emerging mechanisms to see how they can be put together in more or less cohesive structure and how they can help to improve immune response to tumors. This monograph will, for the first time, present a comprehensive overview of different mechanisms of immune dysfunction in cancer as well as therapeutic approaches to their correction. It will discuss a number of new mechanisms that have never been discussed in a monograph before: T-cell inhibitory molecules, regulatory tolerogenic DCs, and signaling pathways in antigen-presenting cells involved in T-cell tolerance.

Reviews

From the reviews:

"The overall goal of this book is to describe what is currently known about the ways tumors circumvent destruction by the host’s immune system. … The book is targeted at researchers -- immunologists in general and, more specifically, tumor immunologists. It also provides a good source of information for graduate students and postdoctoral fellows. The editors of the book and the authors of the chapters are authorities in the areas they discuss. … a useful addition to the field." (Marion C. Cohen, Doody’s Review Service, August, 2008)

Editors and Affiliations

  • H. Lee Moffitt Cancer Center, University of South Florida, Tampa, USA

    Dmitry I. Gabrilovich

  • Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, USA

    Arthur A. Hurwitz

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