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  • © 2010

Molecularly Targeted Therapy for Childhood Cancer

  • This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.
  • This book will be the first to comprehensively explore the molecular aspects of childhood cancers that make them vulnerable to certain potential therapeutic approaches.
  • Includes supplementary material: sn.pub/extras

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xviii
  2. Hematologic Malignancies

    1. Front Matter

      Pages 1-1
    2. Molecular Targeted Therapies in T-Cell Acute Lymphoblastic Leukemia

      • Alejandro Gutierrez, A. Thomas Look
      Pages 19-30
    3. Molecularly Targeted Therapy for Infant ALL

      • Patrick A. Brown, Carolyn A. Felix
      Pages 31-58
    4. Targeted Therapeutic Approaches for AML

      • Robert J. Arceci, Donald Small
      Pages 59-82
    5. Acute Promyelocytic Leukaemia

      • Andrea Biondi, Anna Maria Testi, Brenda E. S. Gibson
      Pages 83-108
    6. Down Syndrome and Acute Myeloid Leukemia: An Unique Genetic Sensitivity to Chemotherapy

      • Jeffrey W. Taub, Yubin Ge, Yaddanapudi Ravindranath
      Pages 109-122
    7. Targeting RAS Signaling Pathways in Juvenile Myelomonocytic Leukemia (JMML)

      • Jennifer O’Hara Lauchle, Benjamin S. Braun
      Pages 123-138
    8. Chronic Myeloid Leukemia: Pathophysiology and Therapeutics

      • Seth J. Corey, Jorge Cortes
      Pages 139-153
    9. New Therapeutic Frontiers for Childhood Non-Hodgkin Lymphoma

      • Megan S. Lim, Mitchell S. Cairo
      Pages 177-213
    10. Molecular Targeting of Post-transplant Lymphoproliferative Disorders

      • Michael Wang, Thomas G. Gross
      Pages 215-228
  3. Solid Tumors

    1. Front Matter

      Pages 299-299
    2. Future Treatments of Ependymoma

      • Richard J. Gilbertson
      Pages 291-304
    3. Molecular Therapy for Neuroblastoma

      • Yaël P. Mossé, John M. Maris
      Pages 351-371

About this book

Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular ‘drivers’ can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered.

This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.

Editors and Affiliations

  • Director, Center for Childhood Cancer, Nationwide Children’s Hospital, The Research Institute, Columbus, USA

    Peter J. Houghton

  • Johns Hopkins The Bunting & Blaustein Ca, Medicine Kimmel Comprehensive Cancer Cen, Baltimore, USA

    Robert J. Arceci

Bibliographic Information

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access