Editors:
- Discusses the latest developments in the area of lymphocyte activation and immune regulation
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 596)
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Table of contents (18 papers)
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Front Matter
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Back Matter
About this book
In recent years, major developments have been made in understanding various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. A role and mechanism of DNA repair proteins in somatic hypermutation has been elucidated. Genetic mutation studies have been instrumental in providing insight into some of the mechanisms involved in targeting CSR to various switch DNA regions located upstream of C region genes, especially a role of AID motifs, transcription, and R-loops. Recent studies support a dominant role of receptor editing in central B cell tolerance and signaling pathways that regulate receptor editing in self-reactive and non-self-reactive immature B cells. These were some of the topics of discussion at the 11th International Conference on B cell Biology. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.
Editors and Affiliations
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School of Medicine, College of Health Sciences, University of California, Irvine, USA
Sudhir Gupta
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Department of Genetics, Children's Hospital Boston, Boston, USA
Frederick Alt
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Inst. Medical/Tumor Research Laboratories, University of Alabama, Birmingham, USA
Max Cooper
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BiozentrumAbt. Zellbiologie, Max Planck Institute for Infection Biology, Berlin, 4056, Germany
Fritz Melchers
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Center for Blood Research, Harvard Medical School, Boston, USA
Klaus Rajewsky
Bibliographic Information
Book Title: Mechanisms of Lymphocyte Activation and Immune Regulation XI
Book Subtitle: B Cell Biology
Editors: Sudhir Gupta, Frederick Alt, Max Cooper, Fritz Melchers, Klaus Rajewsky
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/0-387-46530-8
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2007
Hardcover ISBN: 978-0-387-46527-2Published: 06 February 2007
Softcover ISBN: 978-1-4419-4283-8Published: 19 November 2010
eBook ISBN: 978-0-387-46530-2Published: 21 May 2007
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: X, 198
Number of Illustrations: 44 b/w illustrations
Topics: Immunology, Infectious Diseases, Microbiology, Virology, Pharmacology/Toxicology