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  • Book
  • © 2006

Gene Expression and Regulation

Editors:

  1. Jun Ma

    1. Division of Developmental Biology Cincinnati Children’s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, USA

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  • Provides comprehensive coverage of the science of gene expression and regulation
  • Edited by an expert in the field
  • Concentrates on concepts and issues, rather than specific organisms or experimental approaches

  • 44k Accesses

Sections

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Table of contents (35 chapters)

  1. Front Matter

    Pages i-vi
    PDF

  2. The History

    1. Front Matter

      Pages 1-1
      PDF

    2. Transcription: The Never Ending Story

      • James A. Goodrich, Robert Tjian
      Pages 3-18

  3. The Machinery

    1. Front Matter

      Pages 19-19
      PDF

    4. General Cofactors: TFIID, Mediator and USA

      • Mary C. Thomas, Cheng-Ming Chiang
      Pages 67-94

    5. Chromatin and Regulation of Gene Expression

      • Joseph H. Taube, Michelle Craig Barton
      Pages 95-109

    6. HATs and HDACs

      • Timothy A. Bolger, Todd Cohen, Tso-Pang Yao
      Pages 111-133

  4. The Regulators

    1. Front Matter

      Pages 145-145
      PDF

    3. Transcriptional Repressors and Repression Mechanisms

      • Lorena Perrone, Hitoshi Aihara, Yutaka Nibu
      Pages 159-173

    5. Transcriptional Regulation by Smads

      • Fang Liu
      Pages 185-206

    6. The Rb and E2F Families of Proteins

      • Wei Du, Jennifer Pogoriler
      Pages 207-217

    8. HIV Tat and the Control of Transcriptional Elongation

      • Ruichuan Chen, Qiang Zhou
      Pages 239-256

    9. Post-translational Modifications of the p53 Transcription Factor

      • Christopher L. Brooks, Wei Gu
      Pages 257-272

    10. Actions of Nuclear Receptors

      • Kurt Schillinger, Sophia Y. Tsai, Ming-Jer Tsai
      Pages 273-292
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About this book

All genes must be expressed to exhibit their biological activities. How genes are expressed and regulated is a central question in molecular biology and our knowledge in this area has been expanding enormously in recent years. The complexity of gene regulation is compounded by the fact that gene activities reach every comer of biology. Transcription is universally the first step toward expressing a gene. It is a highly regulated process. Understanding the molecular mechanisms of transcription regulation is of fiindamental importance. For protein-coding genes, post-transcriptional steps, including pre-mRNA processing, mRNA transport and translation, can also play important roles in regulating gene expression. To contain the scope of this book, we will focus primarily on RNA polymerase II transcription and regulation. We will explore not only the biochemical basis of transcription but also the biological consequences of, and biological influences on gene transcription. The book is composed of 35 individual review articles written by authorities in the field. The chapters are organized into five sections: The History, The Machinery, The Regulators, The Genome, and Special Topics. The History section contains one chapter, written by James Goodrich and Robert Tjian, who provide an excellent historical perspective and overview of the transcription process. The Machinery section has six chapters that cover essential topics on the transcriptional apparatus, general cofactors, chromatin structure, and core promoter structure.
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Keywords

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Editors and Affiliations

  • Division of Developmental Biology Cincinnati Children’s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, USA

    Jun Ma

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About the editor

Jun Ma, PhD, is an Associate Professor, Division of Developmental Biology, Cincinnati Children’s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

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Bibliographic Information

  • Book Title: Gene Expression and Regulation

  • Editors: Jun Ma

  • DOI: https://doi.org/10.1007/978-0-387-40049-5

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag New York 2006

  • Edition Number: 1

  • Number of Pages: VIII, 582

  • Number of Illustrations: 45 b/w illustrations, 91 illustrations in colour

  • Additional Information: Jointly published with Higher Education Press (HEP), Beijing, China

  • Topics: Molecular Medicine

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