Overview
- Each chapter is written by a leader in the field
- Contains detailed illustrations
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 593)
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Table of contents (14 chapters)
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Front Matter
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Applications in the Oncology Field
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Back Matter
Keywords
About this book
Cancer is a heterogeneous disease in most respects, including its cellularity, different genetic alterations and diverse clinical behaviors. Traditional molecular analyses are reductionist, assessing only one or a few genes at a time, thus working with a biologic model too specific and limited to confront a process whose clinical outcome is likely to be governed by the combined influence of many genes. The potential of functional genomics is enormous, because for each experiment, thousands of relevant observations can be made simultaneously. Accordingly, DNA array, as other high throughput technologies, might catalyze and ultimately accelerate the development of knowledge in tumor cell biology. Although in its infancy, the implementation of DNA array technology in cancer research has already provided investigators with novel data and intriguing new hypotheses on the molecular cascade leading to cancerogenesis, tumor aggressiveness and sensitivity to antineoplastic agents. Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, principles of DNA array-based tumor gene profiling need to be clearly understood for the data to be correctly interpreted and appreciated. In the present book, written by leading experts in each field, the technical features characterizing this powerful laboratory tool are discussed, and the applications so far described in the field of oncology are reviewed.
Editors and Affiliations
Bibliographic Information
Book Title: Microarray Technology and Cancer Gene Profiling
Editors: Simone Mocellin
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-0-387-39978-2
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2007
Hardcover ISBN: 978-0-387-39977-5Published: 04 December 2006
Softcover ISBN: 978-1-4419-2298-4Published: 19 November 2010
eBook ISBN: 978-0-387-39978-2Published: 28 August 2007
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XVIII, 159
Topics: Oncology, Cancer Research