Radiation Oncology Advances

1. Front Matter

   Pages i-xvi

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2. Advances in Imaging and Biologically-Based Treatment Planning

   1. Front Matter

      Pages 5-5

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   2. Radiation Oncology Advances: An Introduction

      • Søren M. Bentzen, Paul M. Harari, Wolfgang A. Tomé, Minesh P. Mehta

      Pages 1-4

   3. Advanced Image-Guided External Beam Radiotherapy

      • Thomas Rockwell Mackie, Wolfgang A. Tomé

      Pages 7-39

   4. Dose Painting and Theragnostic Imaging: Towards the Prescription, Planning and Delivery of Biologically Targeted Dose Distributions in External Beam Radiation Oncology

      • Søren M. Bentzen

      Pages 40-61

   5. Molecular and Functional Imaging in Radiation Oncology

      • Robert Jeraj, M. Elizabeth Meyerand

      Pages 62-94

   6. Prognostic and Predictive Markers in Radiation Therapy: Focus on Prostate Cancer

      • Mark A. Ritter

      Pages 95-112

3. Advances in Molecular Biology and Targeted Therapies

   1. Front Matter

      Pages 113-113

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   2. Overview of Cancer Molecular Radiobiology

      • Jann N. Sarkaria, Robert G. Bristow

      Pages 115-131

   3. Clinical Application of EGFR Inhibitors in Head and Neck Squamous Cell Cancer

      • Igor Astsaturov, Roger B. Cohen, Paul M. Harari

      Pages 132-149

   4. Advancement of Antiangiogenic and Vascular Disrupting Agents Combined with Radiation

      • Deborah Citrin, Kevin Camphausen

      Pages 150-168

   5. Overcoming Therapeutic Resistance in Malignant Gliomas: Current Practices and Future Directions

      • Arnab Chakravarti, Kamalakannan Palanichamy

      Pages 169-185

4. Advances in Treatment Delivery and Planning

   1. Front Matter

      Pages 187-187

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   2. Advances in Intensity-Modulated Radiotherapy Delivery

      • John D. Fenwick, Stephen W. Riley, Alison J. D. Scott

      Pages 189-210

   3. Image-Based Modeling of Normal Tissue Complication Probability for Radiation Therapy

      • Joseph O. Deasy, Issam El Naqa

      Pages 211-252

   4. Optimization of Radiotherapy Using Biological Parameters

      • Yusung Kim, Wolfgang A. Tomé

      Pages 253-274

5. Clinical Advances

   1. Front Matter

      Pages 275-275

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   2. Combined Chemoradiotherapy Advances

      • Gordon Wong, Minesh P. Mehta

      Pages 277-301

   3. Cytoprotection for Radiation-Associated Normal Tissue Injury

      • Jingfang Mao, Oluwatoyosi A. Fatunase, Lawrence B. Marks

      Pages 302-322

6. Back Matter

   Pages 323-336

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from combining radiation with a molecular targeted agent – namely cetuximab, a recombinant mouse/human chimeric monoclonal antibody against the Epidermal Growth Factor (EGF) receptor [4] Astsaturov, Cohen and Harari present a more indepth review of the biology of the EGF Receptor and its signaling pathway in Chap. 7 as a potential target in combination with fractionated radiotherap y for head and neck squamous cell carcinoma (HNSCC). A flurry of agents are under de velopment for targeting EGFR and in March 2006, the US Food and Drugs Administration approved cetuximab combined with radiation as a primary treatment option for patients with loco-regionally advanced HNSCC in whom chemoradiation therapy is deemed not to be an option. While blocking the EGF pathway during fractionated radiotherapy may seem an obvious strategy [5], the rationale for combining antiangiogenic and antivascular targeting agents with radiation may be less intuitive. However, recent research shows that there are several reasons why this could result in a therapeutic gain in practice. Chapter 8 is a review of this rapidly expanding field by Citrin and Camphausen. Targeted agents combined with radiation may offer new opportunities in the treatment of central nervous system malignancies, a tumor type where the outlook remains poor despite some recent progress [6]. Current attempts to overcome rad- tion resistance in these tumors on the basis of an improved understanding of their molecular biology are the topic of Chap. 9 by Chakravarti and Palanichamy.

• brachytherapy
• cancer
• cell
• imaging
• magnetic resonance imaging (MRI)
• molecular biology
• molecular imaging
• positron emission tomography (PET)
• prostate cancer
• radiation
• radiation oncology
• radiobiology
• radiotherapy
• Radiaton Oncology
• Diagnostic Radiology

From the reviews:

"Major advances in radiation oncology ... are reviewed in this book. ... Resident, attending and practicing radiation oncologists are the intended audience. The authors are respected radiation oncology practitioners and researchers. ... This excellent account of the major recent advances in radiation oncology is well written and edited. ... It is useful for both practicing and in-training radiation oncologists." (Jyoti Mayadev, Doody's Review Service, December, 2008)

• University of Wisconsin School of Medicine and Public Health, Madison, USA

  Søren M. Bentzen, Paul M. Harari, Wolfgang A. Tomé, Minesh P. Mehta

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