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Tight Junctions

  • Book
  • © 2006

Overview

Authors:
  1. Lorenza Gonzalez-Mariscal

    1. Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies (CINVESTAV), México D.F., México

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  • Tight Junctions is particularly relevant to students and scientists in the field of cell biology, physiology, cell differentiation, and cancer research
  • Deals with TJs of central nervous system myelin and at the blood brain barrier, thus shedding new light on autoimmune diseases and the protection of the microenvironment of the central nervous system
  • Includes supplementary material: sn.pub/extras

Part of the book series: Molecular Biology Intelligence Unit (MBIU)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Evolution of the Transporting Epithelium Phenotype

    • Marcelino Cereijido, María del Refugio García-Villegas, Liora Shoshani, Ruben Gerardo Contreras
    Pages 1-18

  3. Occludin, a Constituent of Tight Junctions

    • Yan-Hua Chen, Daniel A. Goodenough, Qun Lu
    Pages 19-32

  4. Tight Junction Channels

    • James Melvin Anderson, Christina M. Van Itallie
    Pages 33-42

  5. JAM Family Proteins

    • Susumu Hirabayashi, Yutaka Hata
    Pages 43-53

  6. Cingulin, a Cytoskeleton-Associated Protein of the Tight Junction

    • Laurent Guillemot, Sandra Citi
    Pages 54-63

  7. ZO Proteins and Tight Junction Assembly

    • Alan S. Fanning
    Pages 64-75

  8. TJ Proteins That Make Round Trips to the Nucleus

    • Esther Lopez-Bayghen, Blanca Estela Jaramillo, Miriam Huerta, Abigail Betanzos, Lorenza Gonzalez-Mariscal
    Pages 76-100

  9. Tight Junctions and the Regulation of Epithelial Cell Proliferation and Gene Expression

    • Emma Kavanagh, Anna Tsapara, Karl Matter, Maria S. Balda
    Pages 101-115

  10. Tight Junction Proteins and Cancer

    • Isabel J. Latorre, Kristopher K. Frese, Ronald T. Javier
    Pages 116-134

  11. Regulation of Paracellular Transport across Tight Junctions by the Actin Cytoskeleton

    • Matthias Bruewer, Asma Nusrat
    Pages 135-145

  12. Regulation of Tight Junctions’ Functional Integrity

    • Liora Shoshani, David Flores-BenÍtez, Lorenza Gonzalez-Mariscal, Rubén Gerardo Contreras
    Pages 146-163

  13. Tight Junctions during Development

    • Bhavwanti Sheth, Judith Eckert, Fay Thomas, Tom P. Fleming
    Pages 164-174

  14. Tight Junctions and the Blood-Brain Barrier

    • Hartwig Wolburg, Andrea Lippoldt, Klaus Ebnet
    Pages 175-195

  15. Tight Junctions in CNS Myelin

    • Jeff M. Bronstein, Seema Tiwari-Woodruff
    Pages 196-205

  16. Tight Junction Modulation and Its Relationship to Drug Delivery

    • Noha N. Salama, Natalie D. Eddington, Alessio Fasano
    Pages 206-219

  17. Back Matter

    Pages 221-224
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Keywords

About this book

ight junctions (TJs) are cell-ceil adhesion belts that encircle epithelial and endothelial cells at the limit between the apical and the lateral Tmembrane. These junctions are crucial for the establishment of separate compartments in multicellular organisms and for the exchange of substances between the internal milieu and the external environment. The perception of TJs has changed over the years. From being regarded as static paracellular seals, they have come to be perceived as dynamic structures that adjust their morphol­ ogy and function in response to physiological, pharmacological and pathologi­ cal challenges. The roles that TJs play in epithelial and endothelial cells has also widened, and nowadays this structure is regarded not only as a fence that limits within the membrane, the movement of proteins and lipids between the apical and basolateral membranes, or as a gate that regulates in a size and charge selec­ tive manner the transit of ion and molecules through the paracellular pathway, but also as a structure integrated by molecules that participate in the control of cell proliferation. These observations highlight the importance of understand­ ing TJ physiology in order to develop effective strategies for the treatment of pathological conditions such as cancer and autoimmune diseases. This broader perception of TJs is reflected in all the chapters of the book and has been attained thanks to the identification in recent years of a wide array of proteins that constitute TJs in epithelial and endothelial cells as well as in central nervous system myelin.

Authors and Affiliations

  • Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies (CINVESTAV), México D.F., México

    Lorenza Gonzalez-Mariscal

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