Sigma Receptors

1. Front Matter

   Pages i-xi

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2. σ Receptors: Historical Perspective and Background

   • Rae R. Matsumoto

   Pages 1-23

3. Medicinal Chemistry: New Chemical Classes and Subtype-Selective Ligands

   • Amy Hauck Newman, Andrew Coop

   Pages 25-44

4. Irreversible σ Compounds

   • Giuseppe Ronsisvalle, Orazio Prezzavento

   Pages 45-69

5. Pharmacophore Models for σ1 Receptor Binding

   • Seth Y. Ablordeppey, Richard A. Glennon

   Pages 71-98

6. Cloning of σ1 Receptor and Structural Analysis of Its Gene and Promoter Region

   • Vadivel Ganapathy, Malliga E. Ganapathy, Katsuhisa lnoue

   Pages 99-112

7. Site-Directed Mutagenesis

   • Hideko Yamamoto, Toshifumi Yamamoto, Keiko Shinohara Tanaka, Mitsunobu Yoshii, Shigeru Okuyama, Toshihide Nukada

   Pages 113-125

8. σ Receptor Modulation of Ion Channels

   • Chris P. Palmer, Ebru Aydar, Meyer B. Jackson

   Pages 127-149

9. Subcellular Localization and Interacellular Dynamics of σ1 Receptors

   • Teruo Hayashi, Tsung-Ping Su

   Pages 151-164

10. Intracellular Signaling and Synaptic Plasticity

    • Francois P. Monnet

    Pages 165-193

11. Modulation of Classical Neurotransmitter Systems by σ Receptors

    • Linda L. Werling, Alicia E. Derbez, Samer J. Nuwayhid

    Pages 195-214

12. σ2 Receptors: Regulation of Cell Growth and Implications for Cancer Diagnosis and Therapeutics

    • Wayne D. Bowen

    Pages 215-235

13. Cognitive Effects of σ Receptor Ligands

    • Tangui Maurice

    Pages 237-271

14. σ Receptors and Scizophrenia

    • Xavier Guitart

    Pages 273-292

15. Potential Role of σ Ligands and Neurosteroids in Major Depression

    • Guy Debonnel, Malika Robichaud, Jordanna Bermack

    Pages 293-314

16. σ Receptors and Drug Abuse

    • Yun Liu, Yongxin Yu, Jamaluddin Shaikh, Buddy Pouw, AnTawan Daniels, Guang-Di Chen et al.

    Pages 315-336

17. σ1 Receptors and the Modulation of Opiate Analgesics

    • Gavril W. Pasternak

    Pages 337-350

18. σ Receptors in the Immune System: Implications for Potential Therapeutic Intervention - An Overview

    • Sylvaine Galiegue, Hubert Vidal, Pierre Casellas

    Pages 351-370

19. σ Receptors and Gastrointestinal Function

    • Francois J. Roman, Maria Chovet, Lionel Bueno

    Pages 371-391

20. Back Matter

    Pages 393-414

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Over the last 30 years, our understanding of a receptors has undergone a colossal evolution. They began as theoretical entities, then progressed to enigmatic receptors, and finally to identified proteins with important biological functions. Since the first book on a receptors was published in 1994, there have been many significant advances in the field. We now know that o receptors subserve many critical functions in the body and recent studies indicate that they are promising drug development targets for a host of neurological, psychiatric, cardiovascular, ophthalmological, immunological, and gastrointestinal disorders. This book provides a timely update on the medicinal chemistry, cell biology, and clinical implications of a receptors. It puts the information in a historical perspective to help new comers to the field successfully navigate the confusing early history surrounding these proteins, and it provides a launching point from which future studies and research directions can easily be developed. The full impact of a receptors on biological function has yet to be determined. The existing gaps in our knowledge base offer untold opportunities for future research. It is our hope that the information contained in this book will stimulate new, exciting research on a receptors and ultimately lead to innovative insights into basic biological mechanisms and novel therapeutic advances.

• Depression
• Immune System
• Intervention
• Promoter
• Regulation
• cell biology
• diagnosis
• genes
• lead
• medicinal chemistry
• molecular biology
• proteins

• National Institute on Drug Abuse, Bethesda

  Tsung-Ping Su

• University of Mississippi, University

  Rae R. Matsumoto

• Brown University, Providence

  Wayne D. Bowen

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