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Polyomaviruses and Human Diseases

  • Book
  • © 2006

Overview

Editors:
  1. Nasimul Ahsan

    1. Mayo Clinic Transplant Center, Mayo Clinic - College of Medicine, Jacksonville, USA

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  • Written by a pioneer in the field with extensive experience studying or treating the virus
  • Most current and up-to-date information on polyomavirus and its associated diseases

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 577)

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xxiv
    Download chapter PDF

  2. Polyomaviruses and Human Diseases

    • Nasimul Ahsan, Keerti V. Shah
    Pages 1-18

  3. Discovery and Epidemiology of the Human Polyomaviruses BK Virus (BKV) and JC Virus (JCV)

    • Wendy A. Knowles
    Pages 19-45

  4. Phylogenomics and Molecular Evolution of Polyomaviruses

    • Keith A. Crandall, Marcos Prérez-Losada, Ryan G. Christensen, David A. McClellan, Raphael P. Viscidi
    Pages 46-59

  5. Virus Receptors and Tropism

    • Aarthi Ashok, Walter J. Atwood
    Pages 60-72

  6. Serological Cross Reactivity between Polyomavirus Capsids

    • Raphael P. Viscidi, Barbara Clayman
    Pages 73-84

  7. Molecular Genetics of the BK Virus

    • Christopher L. Cubitt
    Pages 85-95

  8. Serological Diagnosis of Human Polyomavirus Infection

    • Annika Lundstig, Joakim Dillner
    Pages 96-101

  9. Human Polyomavirus JC and BK Persistent Infection

    • Kristina Doerries
    Pages 102-116

  10. Immunity and Autoimmunity Induced by Polyomaviruses

    • Ole Petter Rekvig, Signy Bendiksen, Ugo Moens
    Pages 117-147

  11. The Pathobiology of Polyomavirus Infection in Man

    • Parmjeet Randhawa, Abhay Vats, Ron Shapiro
    Pages 148-159

  12. Polyomavirus-Associated Nephropathy in Renal Transplantation

    • Hans H. Hirsch, Cinthia B. Drachenberg, Juerg Steiger, Emilio Ramos
    Pages 160-173

  13. BK Virus and Immunosuppressive Agents

    • Irfan Agha, Daniel C. Brennan
    Pages 174-184

  14. BK Virus Infection after Non-Renal Transplantation

    • Martha Pavlakis, Abdolreza Haririan, David K. Klassen
    Pages 185-189

  15. Latent and Productive Polyomavirus Infections of Renal Allografts

    • Volker Nickeleit, Harsharan K. Singh, Michael J. Mihatsch
    Pages 190-200

  16. Urine Cytology Findings of Polyomavirus Infections

    • Harsharan K. Singh, Lukas Bubendorf, Michael J. Mihatsch, Cinthia B. Drachenberg, Volker Nickeleit
    Pages 201-212

  17. Diagnosis and Treatment of BK Virus-Associated Transplant Nephropathy

    • Abhay Vats, Parmjeet Randhawa, Ron Shapiro
    Pages 213-227

  18. Pharmacotherapeutic Options for the Management of Human Polyomaviruses

    • Julie Roskopf, Jennifer Trofe, Robert J. Stratta, Nasimul Ahsan
    Pages 228-254

  19. Leflunomide in Solid Organ Transplantation and Polyoma Virus Infection

    • Michelle A. Josephson, Basit Javaid, Pradeep V. Kadambi, Shane M. Meehan, James W. Williams
    Pages 255-265

  20. JC Virus Can Infect Human Immune and Nervous System Progenitor Cells

    • Jean Hou, Pankaj Seth, Eugene O. Major
    Pages 266-273
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Keywords

About this book

Science never solves apr oblem without creating ten more Geor ge Bernard Shaw How prophetic the above words prove to be when applied to the advances of 20th century medicine. Prior to Banting and Best, chnicians were unaware of the ravages of diabetes, patients simply wasted away and died. Following the purifica­ tion of insulin, clinicians now had to deal with diabetic retinopathy, diabetic neph­ ropathy and all the other complications of long-term diabetes. A little over 50 years ago, the first successful human kidney transplant was performed in Boston. The first 30 years of the experience had successes when compared to the alternative but were a constant struggle to get even 50% of the grafts from deceased donors to survive more than a year. However, the science continued to advance knowledge of the immune response. With this came more and increasingly powerful tools for the clinician. Suddenly, success rates of 80-90% at one year were attainable. With this success came new problems, new complications and clinicians now had to worry about the long-term consequences of their therapy as patients were surviving with functional grafts for extended periods. A particular infectious complication evolved with the application of ever more powerful immunosuppressant drugs. Astute clinicians noted that occasionally cellular rejections seemed to get worse with steroids. Despite their best efforts and the use of powerful drugs, patients lost their grafts to overwhelming interstitial infiltrates not seen before.

Editors and Affiliations

  • Mayo Clinic Transplant Center, Mayo Clinic - College of Medicine, Jacksonville, USA

    Nasimul Ahsan

Bibliographic Information

  • Book Title: Polyomaviruses and Human Diseases

  • Editors: Nasimul Ahsan

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/0-387-32957-9

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2006

  • Hardcover ISBN: 978-0-387-29233-5Published: 02 February 2006

  • Softcover ISBN: 978-1-4419-2122-2Published: 19 November 2010

  • eBook ISBN: 978-0-387-32957-4Published: 25 June 2007

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XXIV, 360

  • Number of Illustrations: 60 b/w illustrations, 19 illustrations in colour

  • Topics: Immunology, Infectious Diseases, Pathology, Neurology, Oncology

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