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Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules

  • Book
  • © 2006

Overview

Authors:
  1. Christopher G. Janson

    1. Departments of Neurosurgery, Neurology and Molecular Genetics Cell and Gene Therapy Center, UMDNJ-Robert Wood Johnson Medical School, Camden, USA

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    You can also search for this author in PubMed   Google Scholar

  2. Matthew J. During

    1. Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand

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    You can also search for this author in PubMed   Google Scholar

  • Distinguished list of authors, many of whom are among the leaders or founders in the field
  • Broader overview of the field than existing literature
  • Bridges the gap from the bench to the bedside
  • Includes supplementary material: sn.pub/extras

Part of the book series: Medical Intelligence Unit (MIUN)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Research Applications

    1. Front Matter

      Pages 1-1
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    2. The Many Faces of PNA

      • Peter E. Nielsen
      Pages 3-17

    3. Modulation of Nucleic Acid Information Processing by PNAs

      • Lionel Bastide, Bernard Lebleu, Ian Robbins
      Pages 18-29

    4. Targeted Gene Delivery

      • Kenneth W. Liang, Feng Liu, Leaf Huang
      Pages 30-37

    5. Imaging Gene Expression in the Brain with Peptide Nucleic Acid (PNA) Antisense Radiopharmaceuticals and Drug Targeting Technology

      • Ruben J. Boado, William M. Pardridge
      Pages 38-60

    6. Receptor-Specific Targeting with Complementary Peptide Nucleic Acids Conjugated to Peptide Analogs and Radionuclides

      • Eric Wickstrom, Mathew L. Thakur, Edward R. Sauter
      Pages 61-88

    7. Morpholinos and PNAs Compared

      • James E. Summerton
      Pages 89-113

    8. Chemistry of Locked Nucleic Acids (LNA)

      • Jesper Wengel, Michael Petersen, Miriam Frieden, Troels Koch
      Pages 114-132

    9. Recent Applications of RNA Interference (RNAi) in Mammalian Systems

      • Lisa Scherer, John J. Rossi
      Pages 133-147

  3. Clinical Applications

    1. Front Matter

      Pages 149-149
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    2. Peptide Nucleic Acids as Epigenetic Inhibitors of HIV-1

      • Shizuko Sei
      Pages 151-170

    3. Therapeutic Uses of Peptide Nucleic Acids (PNA) in Oncology

      • Nadia Zaffaroni, Raffaella Villa, Marco Folini
      Pages 171-180

    4. PNAs as Novel Cancer Therapeutics

      • Luca Mologni, Carlo Gambacorti-Passerini
      Pages 181-194

    5. Medicinal Chemistry of Plasmid DNA with Peptide Nucleic Acids

      • Olivier Zelphati, Jiin Felgner, Yan Wang, Xiaowu Liang, Xiaodong Wang, Philip Felgner
      Pages 195-211

    6. Locked Nucleic Acids (LNA) and Medical Applications

      • Henrik Ørum, Andreas Wolter, Lars Kongsbak
      Pages 212-222

    7. Peptide Nucleic Acids as Agents to Modify Target Gene Expression and Function

      • Gan Wang, Peter M. Glazer
      Pages 223-235

    8. Peptide Nucleic Acids

      • David R. Corey
      Pages 236-242

    9. The Use of PNAs and Their Derivatives in Mitochondrial Gene Therapy

      • Paul M. Smith, Günther F. Ross, Theresa M. Wardell, Robert W. Taylor, Douglass M. Turnbull, Robert N. Lightowlers
      Pages 243-251

    10. Gene Silencing through RNA Interference

      • David O. Azorsa, Spyro Mousses, Natasha J. Caplen
      Pages 252-264
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Keywords

About this book

This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.

Authors and Affiliations

  • Departments of Neurosurgery, Neurology and Molecular Genetics Cell and Gene Therapy Center, UMDNJ-Robert Wood Johnson Medical School, Camden, USA

    Christopher G. Janson

  • Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand

    Matthew J. During

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