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Dipeptidyl Aminopeptidases

Basic Science and Clinical Applications

  • Conference proceedings
  • © 2006

Overview

Editors:
  1. Uwe Lendeckel

    1. Otto-von-Guericke University, Magdeburg, Germany

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  2. Dirk Reinhold

    1. Otto-von-Guericke University, Magdeburg, Germany

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  3. Ute Bank

    1. Otto-von-Guericke University, Magdeburg, Germany

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  • The first comprehensive volume on Dipeptidyl Aminopeptidases that can be marketed to such a wide variety of disciplines (immunology, autoimmune disease, inflammation, neuroscience, drug development/pharmaceutical sciences, and biochemistry), as well as to a variety of clinicians
  • Includes supplementary material: sn.pub/extras

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Table of contents (25 papers)

  1. Front Matter

    Pages i-iv
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  2. Structure and Function

    1. Front Matter

      Pages 1-1
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    2. Peptide Substrates of Dipeptidyl Peptidases

      • Inger Brandt, Anne-Marie Lambeir, Marie-Berthe Maes, Simon Scharpé, Ingrid De Meester
      Pages 3-18

    3. Phosphorus-Containing Inhibitors of Proteolytic Enzymes

      • Angela Stöckel-Maschek, Beate Stiebitz, Bianca Senns, Nils Lindner, Werner Mögelin, Klaus Neubert
      Pages 19-26

    4. Biochemical Properties of Recombinant Prolyl Dipeptidases DPP-IV and DPP8

      • Xin Chen
      Pages 27-32

    5. Prediction of Dipeptidyl Peptidase (DP) 8 Structure by Homology Modelling

      • Melissa R. Pitman, R. Ian Menz, Catherine A. Abbott
      Pages 33-42

  3. Dpiv-Related Enzymes

    1. Front Matter

      Pages 43-43
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    2. Structure and Function in Dipeptidyl Peptidase IV and Related Proteins

      • Mark D. Gorrell, Xin M. Wang, Joohong Park, Katerina Ajami, Denise Ming Tse Yu, Heather Knott et al.
      Pages 45-54

    3. Expression and Function of Dipeptidyl Peptidase IV and Related Enzymes in Cancer

      • Petr Busek, Evzen Krepela, Vladislav Mares, Kvetoslava Vlasicova, Jan Sevcik, Aleksi Sedo
      Pages 55-62

    4. DP8 and DP9 have Extra-Enzymatic Roles in Cell Adhesion, Migration and Apoptosis

      • Denise M. T. Yu, Xin M. Wang, Katerina Ajami, Geoffrey W. McCaughan, Mark D. Gorrell
      Pages 63-72

    5. In Vivo Effects of a Potent, Selective Dppii Inhibitor

      • Marie-Berthe Maes, Anne-Marie Lambeir, Pieter Van der Veken, Benedicte De Winter, Koen Augustyns, Simon Scharpé et al.
      Pages 73-85

    6. Expression of Dipeptidyl Peptidase IV-Like Enzymes in Human Peripheral Blood Mononuclear Cells

      • Sabine Wrenger, Bianca Guth, Bianca Schultze, Torsten Hoffmann, Daniel Friedrich, Thilo Kähne et al.
      Pages 87-91

    7. Dipeptidyl Peptidase 8 Has Post-Proline Dipeptidyl Aminopeptidase and Prolyl Endopeptidase Activities

      • Joohong Park, Katerina Ajami, Denise M. T. Yu, Mark D. Gorrell
      Pages 93-102

    8. Prolyl Endopeptidase Cleaves the Apoptosis Rescue Peptide Humanin and Exhibits an Unknown Post-Cysteine Cleavage Specificity

      • Joachim Wolfgang Bär, Jens-Ulrich Rahfeld, Ingo Schulz, Kathrin Gans, David Ruiz-Carrillo, Susanne Manhart et al.
      Pages 103-108

    9. Distribution of Dipeptidyl Peptidase Iv-Like Activity Enzymes in Canine and Porcine Tissue Sections by RT-PCR

      • Leona Wagner, Torsten Hoffmann, Jens-Ulrich Rahfeld, Hans-Ulrich Demuth
      Pages 109-116

  4. Metabolic Disorders

    1. Front Matter

      Pages 117-117
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    2. Relative Contribution of Incretins to the Glucose Lowering Effect of DP IV Inhibitors in Type 2 Diabetes Mellitus (T2DM)

      • Simon A. Hinke, Raymond A. Pederson, Christopher H. S. McIntosh
      Pages 119-133

    3. Dipeptidyl Peptidase IV: A Molecular Switch of Vascular Actions of Neuropeptide Y

      • Lijun Li, Hans-Ulrich Demuth, Zofia Zukowska
      Pages 135-140

  5. Immune Disorders

    1. Front Matter

      Pages 141-141
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    2. Dipeptidylpeptidase IV (DPIV) and Alanyl-Aminopeptidases (AAPs) as a New Target Complex for Treatment of Autoimmune and Inflammatory Diseases—Proof of Concept in a Mouse Model of Colitis

      • Ute Bank, Janine Tadje, Martin Helmuth, Sofia Stefin, Michael Täger, Carmen Wolke et al.
      Pages 143-153
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Keywords

About this book

Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses, and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in the field will contribute to this book, which will present a state-of-the-art view on these enzymes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent. The sections of the book will focus on various topics including DP IV and related enzymes in: expression and function, metabolic disorders, immune mechanisms and immune disorders, neuronal diseases and cancer, and related drug development.

Editors and Affiliations

  • Otto-von-Guericke University, Magdeburg, Germany

    Uwe Lendeckel, Dirk Reinhold, Ute Bank

Bibliographic Information

  • Book Title: Dipeptidyl Aminopeptidases

  • Book Subtitle: Basic Science and Clinical Applications

  • Editors: Uwe Lendeckel, Dirk Reinhold, Ute Bank

  • DOI: https://doi.org/10.1007/0-387-32824-6

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2006

  • Hardcover ISBN: 978-0-387-29058-4Published: 12 April 2006

  • Softcover ISBN: 978-1-4614-9769-1Published: 15 November 2014

  • eBook ISBN: 978-0-387-32824-9Published: 11 December 2006

  • Edition Number: 1

  • Number of Pages: XXII, 226

  • Topics: Immunology, Infectious Diseases, Neurosciences, Metabolic Diseases, Medical Biochemistry, Diabetes

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