Editors:
Provides a new compilation of information that link changes in the basic structure of synapses and brain diseases, which have not been done yet
Shows that specific secreted proteins, and short peptide mimicking the function of neural cell adhesion molecules can significantly enhance the formation of synapses in the brain
Describes recent advances in research that lay necessary scientific groundwork to develop pharmacological treatments targeting synaptogenesis and allowing us to improve the lives of people affected by brain disorders
Includes supplementary material: sn.pub/extras
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Table of contents (33 chapters)
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Front Matter
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Synaptogenesis: When Long-Distance Relations Become Intimate
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Experimental Models of Synaptogenesis
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Front Matter
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Roles of Cell Adhesion and Secreted Molecules in Synaptic Differentiation
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Front Matter
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Transport of Synaptic Proteins
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Front Matter
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About this book
Some of the molecules critical for building neuronal contacts have been shown to be affected in psychiatric disorders such as autism and mental retardation. Also, a reduction in synapse number in specific brain regions has been found in patients with brain disorders. Thus, imbalance in synaptic contact formation may result in the formation of abnormal neuronal circuits and the aberrant behavior manifested in these brain diseases. Recent findings also suggest that fine tuning of neuronal circuits rather than a major loss of neurons may be the cause of some of these brain disorders. In certain cases, loss of neurons could be a secondary event reflecting problems in improper neuronal communication.
Reviews
From the reviews:
"This volume provides a comprehensive overview and perspectives on the interplay between development, maturity, and disease that is valuable to the newcomer and expert alike. One strength of this volume is that it highlights the breadth of the many experimental systems and approaches that are used to study normal development as well as synaptic defects associated with human diseases. … This volume provides an excellent resource to both established investigators and newcomers to the field." (Ethan G. Hughes and Rita J. Balice-Gordon, Neuron, Vol. 53, 2007)
Editors and Affiliations
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University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Alexander Dityatev
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University of British Columbia, Vancouver, Canada
Alaa El-Husseini
Bibliographic Information
Book Title: Molecular Mechanisms of Synaptogenesis
Editors: Alexander Dityatev, Alaa El-Husseini
DOI: https://doi.org/10.1007/b136369
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag US 2006
Hardcover ISBN: 978-0-387-32560-6Published: 16 August 2006
Softcover ISBN: 978-1-4419-4090-2Published: 29 October 2010
eBook ISBN: 978-0-387-32562-0Published: 24 November 2006
Edition Number: 1
Number of Pages: XXVI, 497
Number of Illustrations: 59 b/w illustrations, 43 illustrations in colour
Topics: Neurosciences