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DNA Conformation and Transcription

  • Book
  • © 2005

Overview

Authors:
  1. Takashi Ohyama

    1. Department of Biology Faculty of Science and Engineering, Konan University, Kobe, Japan

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  • Focuses on functional aspects of DNA structures (conformations), rather than structure and conformation themselves
  • Description of human triplet-repeat diseases and mechanisms of mammalian sex determination
  • The first book to compile the results of +studies that have been performed to date to solve the riddle ‘written’ in DNA conformation
  • Covers almost all of the "famous" DNA structures (conformations) and focuses on their functions in transcription

Part of the book series: Molecular Biology Intelligence Unit (MBIU)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xii
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  2. Multifarious DNA Structures Found In Genomes

    1. Front Matter

      Pages 1-1
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    2. DNA

      • Vladimir N. Potaman, Richard R. Sinden
      Pages 3-17

    3. Sequence-Dependent Variability of B-DNA

      • Victor B. Zhurkin, Michael Y. Tolstorukov, Fei Xu, Andrew V. Colasanti, Wilma K. Olson
      Pages 18-34

  3. Intrinsic DNA Curvature and Transcription

    1. Front Matter

      Pages 35-35
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    2. Curved DNA and Prokaryotic Promoters

      • Munehiko Asayama, Takashi Ohyama
      Pages 37-51

    3. Repression of Transcription by Curved DNA and Nucleoid Protein H-NS

      • Cynthia L. Pon, Stefano Stella, Claudio O. Gualerzi
      Pages 52-65

    4. Curved DNA and Transcription in Eukaryotes

      • Takashi Ohyama
      Pages 66-74

    5. Putative Roles of kin17, a Mammalian Protein Binding Curved DNA, in Transcription

      • Jaime F. Angulo, Philippe Mauffirey, Ghislaine Pinon-Lataillade, Laurent Miccoli, Denis S. F. Biard
      Pages 75-89

  4. Implied Roles of Left-Handed Z-DNA, Triplex DNA, DNA Supercoiling, and Miscellaneous Alternative Conformations of DNA in Transcription

    1. Front Matter

      Pages 91-91
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    2. Roles for Z-DNA and Double-Stranded RNA in Transcription

      • Alan Herbert
      Pages 93-104

    3. Do DNA Triple Helices or Quadruplexes Have a Role in Transcription?

      • Michael W. Van Dyke
      Pages 105-126

    4. Nucleic Acid Structures and the Transcription Defects in Fragile X Syndrome and Friedreich’s Ataxia

      • Karen Usdin
      Pages 127-137

    5. Possible Roles of DNA Supercoiling in Transcription

      • Susumu Hirose, Kuniharu Matsumoto
      Pages 138-143

  5. DNA-Bending Proteins: Architectural Regulation of Transcription

    1. Front Matter

      Pages 145-145
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    2. Gene Regulation by HMGA and HMGB Chromosomal Proteins and Related Architectural DNA-Binding Proteins

      • Andrew A. Travers
      Pages 147-158

    3. Molecular Mechanisms of Male Sex Determination

      • Michael A. Weiss
      Pages 159-173

  6. Chromatin Infrastructure in Transcription: Roles of DNA Conformation and Properties

    1. Front Matter

      Pages 175-175
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    2. The Role of Unusual DNA Structures in Chromatin Organization for Transcription

      • Takashi Ohyama
      Pages 177-188

    3. DNA Bendability and Nucleosome Positioning in Transcriptional Regulation

      • Mensur Dlakić, David W. Ussery, Søren Brunak
      Pages 189-202
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Keywords

About this book

Despite remarkable progress in genome science, we are still far from a clear understanding of how genomic DNA is packaged without entanglement into a nucleus, how genes are wrapped up in chromatin, how chromatin structure is faithfully inherited from mother to daughter cells, and how the differential expression of genes is enabled in a given cell type. Exploring and answering these questions constitutes one of the next frontiers in the 21st century.

We are just beginning to appreciate how Multifarious DNA structures provide additional structural and functional dimensions to chromatin organization and gene expression. DNA Conformation and Transcription is the first book that compiles the fruits of the studies that have been performed to date to solve the riddle ‘written’ in DNA conformation ("conformation code"). This book provides a comprehensive overview of the field by covering history of the field, up-to-date topics, clarifications of present day research, and future perspective of what is still to be discovered. Thus, it serves as an invaluable source of information on the "conformation code".

Authors and Affiliations

  • Department of Biology Faculty of Science and Engineering, Konan University, Kobe, Japan

    Takashi Ohyama

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