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Malaria

Genetic and Evolutionary Aspects

  • Book
  • © 2006

Overview

Authors:
  1. Krishna R. Dronamraju

    1. Foundation for Genetic Research, Houston, USA

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  2. Paolo Arese

    1. Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy

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  • An edited collection of papers by leading experts on the population genetics and evolutionary biology of malaria
  • Includes supplementary material: sn.pub/extras

Part of the book series: Emerging Infectious Diseases of the 21st Century (EIDC)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xi
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  2. Introduction

    • Krishna R. Dronamraju
    Pages 1-12

  3. J.B.S. Haldane (1892–1964)

    • Krishna R. Dronamraju
    Pages 13-24

  4. Removal of Early Parasite Forms from Circulation as a Mechanism of Resistance Against Malaria in Widespread Red Blood Cell Mutations

    • Paolo Arese, Kodjo Ayi, Aleksei Skorokhod, Franco Turrini
    Pages 25-53

  5. Clinical, Epidemiological, and Genetic Investigations on Thalassemia and Malaria in Italy

    • Stefano Canali, Gilberto Corbellini
    Pages 55-80

  6. Resistance to Antimalarial Drugs: Parasite and Host Genetic Factors

    • Rajeev K. Mehlotra, Peter A. Zimmerman
    Pages 81-124

  7. Evolutionary Origins of Human Malaria Parasites

    • Stephen M. Rich, Francisco J. Ayala
    Pages 125-146

  8. Vector Genetics in Malaria Control

    • V.P. Sharma
    Pages 147-167

  9. The Rate of Mutations of Human Genes

    • J. B. S. Haldane
    Pages 169-174

  10. Disease and Evolution

    • J. B. S. Haldane
    Pages 175-187

  11. Back Matter

    Pages 189-190
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Keywords

About this book

This book was originally conceived at a conference at the University of Turin in Italy. The conference was organized to examine the so-called “Malaria Hypothesis”, that is to say, the higher fitness of t- lassemia heterozygotes in a malarial environment, and to pay tribute to the proponent of that hypothesis, J.B.S. Haldane. Contributors to this book examine certain genetic and evolutionary aspects of malaria which is a major killer of human populations, especially in Africa and Asia. There were attempts to discredit Haldane’s contribution from two directions: (a) it has been suggested that the “Malaria Hypothesis” was known long before Haldane and that there was nothing original about his idea (Lederberg 1999), and that (b) the hypothesis of heterozygote su- riority was first suggested by the Italian biologist Giuseppe Montalenti who communicated his idea to Haldane (Allison 2004). Surely, both c- not be right. In fact, the evidence presented in this book clearly indicates that both are wrong. Haldane’s malaria hypothesis has stimulated a great deal of research on the genetic, evolutionary and epidemiological aspects of malaria d- ing the last 50 years. It has opened up a whole new chapter in the study of infectious diseases. It deserves serious consideration. For helpful discussions we thank Lucio Luzzatto, Alberto Piazza, Guido Modiano and David Roberts.

Reviews

From the reviews:

"Malaria focuses on genetic and evolutionary insights into a paradise blamed for the death of a child every 30 s worldwide. … Malaria: Genetic and Evolutionary Aspects will benefit a broad range of medical, scientific, and public health professionals. Besides strengthening our understanding of the evolutionary origins of malaria, the text opens new perspectives into infectious diseases." (Richard A. Stein, American Journal of Physical Anthropology, Vol. 133, 2007)

Authors and Affiliations

  • Foundation for Genetic Research, Houston, USA

    Krishna R. Dronamraju

  • Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Torino, Italy

    Paolo Arese

Bibliographic Information

  • Book Title: Malaria

  • Book Subtitle: Genetic and Evolutionary Aspects

  • Authors: Krishna R. Dronamraju, Paolo Arese

  • Series Title: Emerging Infectious Diseases of the 21st Century

  • DOI: https://doi.org/10.1007/0-387-28295-5

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag New York 2006

  • Hardcover ISBN: 978-0-387-28294-7Published: 14 December 2005

  • Softcover ISBN: 978-1-4419-2102-4Published: 29 November 2010

  • eBook ISBN: 978-0-387-28295-4Published: 26 June 2006

  • Series ISSN: 1573-4684

  • Series E-ISSN: 2627-5872

  • Edition Number: 1

  • Number of Pages: XI, 190

  • Number of Illustrations: 26 b/w illustrations

  • Topics: Science, Humanities and Social Sciences, multidisciplinary

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