Voltage-Gated Calcium Channels

1. Front Matter

   Pages i-xiv

   PDF

2. Ca2+ Chemistry, Storage and Transport in Biologic Systems

   • Tashi G. Kinjo, Paul P. M. Schnetkamp

   Pages 1-11

3. Monitoring Intracellular Ca2+ in Brain Slices with Fluorescent Indicators

   • Sean J. Mulligan, Brian A. MacVicar

   Pages 12-26

4. A Brief History of Calcium Channel Discovery

   • Richard W. Tsien, Curtis F. Barrett

   Pages 27-47

5. Biochemical Studies of Voltage-Gated Ca2+ Channels

   • William A. Catterall

   Pages 48-60

6. Molecular Properties of Voltage-Gated Calcium Channels

   • Terrance P. Snutch, Jean Peloquin, Eleanor Mathews, John E. McRory

   Pages 61-94

7. Role of β Subunits in Voltage-Gated Calcium Channel Functions

   • Thierry Cens, Sophie Restituito, Matthieu Rousset, Pierre Charnet

   Pages 95-112

8. Distribution and Targeting Mechanisms of Voltage Activated Ca2+ Channels

   • Stefan Herlitze, Melanie D. Mark

   Pages 113-140

9. The Calcium Channel and the Transmitter Release Site

   • Elise F. Stanley, Allen W. Chan

   Pages 141-153

10. Determinants of G Protein Inhibition of Presynaptic Calcium Channels

    • Aparna Nirdosh, Gerald W. Zamponi

    Pages 154-167

11. Phosphorylation-Dependent Regulation of Voltage-Gated Ca2+ Channels

    • Roger A. Bannister, Ulises Meza, Brett A. Adams

    Pages 168-182

12. Ca2+-Dependent Modulation of Voltage-Gated Ca2+ Channels

    • Amy Lee, William A. Catterall

    Pages 183-193

13. Voltage-Dependent Inactivation of Voltage Gated Calcium Channels

    • Mary T. An, Gerald W. Zamponi

    Pages 194-204

14. Selective Permeability of Voltage-Gated Calcium Channels

    • William A. Sather

    Pages 205-218

15. The Run-Down Phenomenon of Ca2+ Channels

    • Klaus J. F. Kepplinger, Christoph Romanin

    Pages 219-230

16. Calcium Channels As Therapeutic Targets

    • Francesco Belardetti, Sian Spacey

    Pages 231-239

17. Calcium Channelopathies

    • Nancy M. Lorenzon, Kurt G. Beam

    Pages 240-261

18. The Molecular Basis of Ca2+ Antagonist Drug Action-Recent Developments

    • Jörg Striessnig, Jean-Charles Hoda, Edwin Wappl, Alexandra Koschak

    Pages 262-280

19. Calcium Channel Block and Inactivation

    • Steffen Hering, Stanislav Sokolov, Stanislav Berjukow, Rainer Marksteiner, Eva Margreiter, Evgeni N. Timin

    Pages 281-293

20. Block of Voltage-Gated Calcium Channels by Peptide Toxins

    • Christina I. Schroeder, Richard J. Lewis, David J. Adams

    Pages 294-308

oltage-gated calcium channels are essential mediators of a range of physiological functions, including the communication between nerve Vcells, the regulation of heart beat, muscle contraction, and secretion of hormones such as insulin. Consequently, these channels are critical phar­ macological targets in the treatment of a variety of disorders, such as epi­ lepsy, hypertension, and pain. Voltage-gated calcium channels have there­ fore been subject to intense study by numerous investigators over the past few decades, and an immense body of work has accumulated. In this book, we provide the first comprehensive overview of our current state of knowl­ edge concerning this exciting field of research. Leading off with a general review of calcium signaling and techniques to measure calcium channel ac­ tivity, the book delves into a provocative overview of the history of the cal­ cium channel field, contributed by one of the key pioneers in the field. Dr. Richard Tsien. This is followed by an in depth review of the biochemical and molecular biological characterization of calcium channel genes by Drs. Catterall and Snutch whose research has resulted in major advances in the calcium channel field. A number of chapters are dedicated towards various aspects of calcium channel structure and function, including channel gat­ ing, permeation, modulation and interactions with members of the exo- totic machinery—contributed by both established leaders and rising stars in the field.

• Activation
• Biophysics
• Peptide
• cardiovascular
• distribution
• genes
• physiology
• regulation

• Department of Physiology and Biophysics, University of Calgary, Calgary, Canada

  Gerald W. Zamponi

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