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Zinc Finger Proteins

From Atomic Contact to Cellular Function

  • Book
  • © 2005

Overview

Editors:
  1. Shiro Iuchi

    1. Department of Cell Biology, Harvard Medical School, Boston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Natalie Kuldell

    1. Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, USA

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    You can also search for this editor in PubMed   Google Scholar

  • The authors include a Nobel Prize laureate, several founders of zinc finger research and the related research fields, and well-known, cutting edge scientists
  • Includes supplementary material: sn.pub/extras

Part of the book series: Molecular Biology Intelligence Unit (MBIU)

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Table of contents (36 chapters)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  2. The Discovery of Zinc Fingers and Their Practical Applications in Gene Regulation: A Personal Account

    1. The Discovery of Zinc Fingers and Their Practical Applications in Gene Regulation: A Personal Account

      • Aaron Klug
      Pages 1-6

  3. Binding of Zinc Fingers to DNA

    1. C2H2 Zinc Fingers As DNA Binding Domains

      • Shiro Iuchi
      Pages 7-13

    2. TFIIIA: A Sophisticated Zinc Finger Protein

      • Raymond S. Brown, Jane Flint
      Pages 14-19

    3. GAGA: Structural Basis for Single Cys2His2 Zinc Finger-DNA Interaction

      • G. Marius Clore, James G. Omichinski
      Pages 20-25

    4. The DNA-Binding Domain of GATA Transcription Factors—A Prototypical Type IV Cys2-Cys2 Zinc Finger

      • Angela M. Gronenborn
      Pages 26-30

    5. MutM: Single C2C2 Zinc Finger-DNA Interaction

      • Ryoji Masui, Noriko Nakagawa, Seiki Kuramitsu
      Pages 31-34

    6. Homing Endonuclease I-TevI: An Atypical Zinc Finger with a Novel Function

      • Patrick Van Roey, Marlene Belfort, Victoria Derbyshire
      Pages 35-38

    7. Zinc Finger Interactions with Metals and Other Small Molecules

      • Jay S. Hanas, Jason L. Larabee, James R. Hocker
      Pages 39-46

    8. Synthetic Zinc Finger Transcription Factors

      • Nicoletta Corbi, Valentina Libri, Claudio Passananti
      Pages 47-55

  4. Binding of Zinc Fingers to RNA

    1. TFIIIA and p43: Binding to 5S Ribosomal RNA

      • Paul J. Romaniuk
      Pages 56-65

    2. RNA Binding by Single Zinc Fingers

      • Martyn K. Darby
      Pages 66-75

    3. Wig-1, a p53-Induced Zinc Finger Protein that Binds Double Stranded RNA

      • Cristina Mendez-Vidal, Fredrik Hellborg, Margareta T. Wilhelm, Magdalena Tarkowska, Klas G. Wiman
      Pages 76-79

    4. Tandem CCCH Zinc Finger Proteins in mRNA Binding

      • Perry J. Blackshear, Ruth S. Phillips, Wi S. Lai
      Pages 80-90

    5. Ribosomal Zinc Finger Proteins: The Structure and the Function of Yeast YL37a

      • John Dresios, Yuen-Ling Chan, Ira G. Wool
      Pages 91-98

  5. Binding of Zinc Fingers to Proteins

    1. LIM Domain and Its Binding to Target Proteins

      • Algirdas Velyvis, Jun Qin
      Pages 99-105

    2. RING Finger-B Box-Coiled Coil (RBCC) Proteins As Ubiquitin Ligase in the Control of Protein Degradation and Gene Regulation

      • Kazuhiro Ikeda, Satoshi Inoue, Masami Muramatsu
      Pages 106-113

    3. Structure and Function of the CBP/p300 TAZ Domains

      • Roberto N. De Guzman, Maria A. Martinez-Yamout, H. Jane Dyson, Peter E. Wright
      Pages 114-120

    4. A Zinc Ribbon Motif Is Essential for the Formation of Functional Tetrameric Protein Kinase CK2

      • Odile Filhol, Maria José Benitez, Claude Cochet
      Pages 121-127

  6. Binding of Zinc Fingers to Small Molecules

    1. The FYVE Finger: A Phosphoinositide Binding Domain

      • Harald Stenmark
      Pages 128-133
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Keywords

About this book

In the early 1980s, a few scientists started working on a Xenopus transcription factor, TFIIIA. They soon discovered a novel domain associated with zinc, and named this domain "zinc finger. " Th e number of proteins with similar zinc fingers grew quickly and these proteins are now called C2H2, Cys2His2 or classical zinc finger proteins. To date, about 24,000 C2H2 zinc finger proteins have been recognized. Approximately 700 human genes, or more than 2% of the genome, have been estimated to encode C2H2 finger proteins. From the beginning these proteins were thought to be numerous, but no one could have predicted such a huge number. Perhaps thousands of scientists are now working on C2H2 zinc finger proteins fi-om variou s viewpoints. This field is a good example of how a new science begins with the insight of a few scientists and how it develops by efforts of numerous independent scientists, in contrast to a policy-driven scientific project, such as the Human Genome Project, with goals clearly set at its inception and with work performed by a huge collaboration throughout the world. As more zinc finger proteins were discovered, several subfamilies, such as C2C2, CCHC, CCCH, LIM, RING, TAZ, and FYVE emerged, increasing our understanding of zinc fingers. The knowledge was overwhelming. Moreover, scientists began defining the term "zinc finger" differently and using various names for identical zinc fingers. These complications may explain why no single comprehensive resource of zinc finger proteins was available before this publication.

Editors and Affiliations

  • Department of Cell Biology, Harvard Medical School, Boston, USA

    Shiro Iuchi

  • Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, USA

    Natalie Kuldell

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