Overview
There is no integrated book on pharmacokinetic-pharmacodynamic modeling that deals with the process of modeling or provides the necessary level of detail to train new modelers.
There is a dearth of pharmacokinetic modelers in industry and academia mainly because there are few training programs and no textbook on the subject. This book will help to fill the void.
Includes supplementary material: sn.pub/extras
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Table of contents (9 chapters)
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Front Matter
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Back Matter
Keywords
About this book
A natural hierarchy exists in pharmacokinetic-pharmacodynamic modeling culminating in population pharmacokinetic models, which are a specific type of nonlinear mixed effects model. The purpose of this book is to present through theory and example how to develop pharmacokinetic models, both at an individual and population level. In order to do so, however, one must first understand linear models and then build to nonlinear models followed by linear mixed effects models and then ultimately nonlinear mixed effects models. This book develops in that manner – each chapter builds upon previous chapters by first presenting the theory and then illustrating the theory using published data sets and actual data sets that were used in the development of new chemical entities collected by the author during his years in industry. A key feature of the book is the process of modeling. Most books and manuscripts often present the final model never showing how the model evolved. In this book all examples are presented in an evolutionary manner.
Authors and Affiliations
Bibliographic Information
Book Title: Pharmacokinetic-Pharmacodynamic Modeling and Simulation
Authors: Peter L. Bonate
DOI: https://doi.org/10.1007/b138744
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag US 2006
eBook ISBN: 978-0-387-27199-6Published: 14 May 2006
Edition Number: 1
Number of Pages: XII, 388
Number of Illustrations: 269 b/w illustrations
Topics: Pharmacology/Toxicology