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Ryanodine Receptors

Structure, function and dysfunction in clinical disease

  • Book
  • © 2005

Overview

Editors:
  1. Xander H. T. Wehrens

    1. Dept. of Physiology and Cellular Biophysics, Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, USA

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  2. Andrew R. Marks

    1. Dept. of Physiology and Cellular Biophysics, Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, USA

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  • Most current publication devoted solely to the major intracellular calcium-release channel, the ryanodine receptor
  • Will quickly bring anyone interested in ryanodine receptors up to speed with its brief but informative chapters
  • Drs. Xander Wehrens and Andrew Marks have gathered the collected wisdom of scientists that have devoted their working lives to the study of ryanodine receptors
  • Includes supplementary material: sn.pub/extras

Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 254)

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-xxi
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  2. Evolution of the Ryanodine Receptor Gene Family

    • Alexander Kushnir, A. K. M. M. Mollah, Xander H. T. Wehrens
    Pages 1-8

  3. Topology and Transmembrane Organization of Ryanodine Receptors

    • Guo Guang Du, David H. MacLennan
    Pages 9-23

  4. Three-Dimensional Reconstruction of Ryanodine Receptors

    • Zheng Liu, Terence Wagenknecht
    Pages 25-34

  5. RYR-DHPR Relationships in Skeletal and Cardiac Muscles

    • Clara Franzini-Armstrong
    Pages 35-41

  6. The Pore of the Ryanodine Receptor Channel

    • Alan J. Williams, S. R. Wayne Chen, William Welch
    Pages 43-52

  7. Intra-Molecular Domain-Domain Interaction

    • Noriaki Ikemoto
    Pages 53-65

  8. Regulation of Sarcoplasmic Reticulum Calcium Release by Luminal Calcium

    • Sandor Györke, Dmitry Terentyev, Serge Viatchenko-Karpinski
    Pages 67-76

  9. Cytosolic Calcium Regulation of Single Ryanodine Receptor Channels

    • Josefina Ramos-Franco, Michael Fill
    Pages 77-86

  10. Elementary Ca2+ Release Events: Ryanodine Receptor Ca2+ Sparks

    • W. J. Lederer, Eric A. Sobie, Silvia Guatimosim, Long-Sheng Song
    Pages 87-97

  11. Ca2+ Release from the Sarcoplasmic Reticulum in Intact Cardiomyocytes

    • Donald M. Bers, Kenneth S. Ginsburg
    Pages 99-109

  12. Stability and Instability of Ca2+ Release from the SR

    • Mary E. Díaz, Stephen C. O’Neill, Andrew W. Trafford, David A. Eisner
    Pages 111-119

  13. Ryanodine Receptors in Smooth Muscle

    • Steven O. Marx
    Pages 121-130

  14. Functions of RYR3 Homologues

    • Yasuo Ogawa, Takashi Murayama, Nagomi Kurebayashi
    Pages 131-140

  15. Knockout Mice Lacking RYR and Junctophilin Subtypes

    • Hiroshi Takeshima
    Pages 141-150

  16. Regulation of Ryanodine Receptor Ca2+ Release by Macromolecular Complexes

    • Xander H. T. Wehrens, Stephan E. Lehnart, Andrew R. Marks
    Pages 151-161

  17. RYR1 Modulation by Calmodulin

    • Paula Aracena, Cecilia Hidalgo, Susan L. Hamilton
    Pages 163-168

  18. Ryanodine Receptor Function in Inflammation

    • Edmond D. Buck, Barbara E. Ehrlich
    Pages 169-178

  19. Ryanoids, Receptor Affinity and RYR Channel Subconductance

    • Henry R. Besch Jr., Chun Hong Shao, Keshore R. Bidasee
    Pages 179-189

  20. Scorpion Peptides as High-Affinity Probes of Ryanodine Receptor Function

    • Georgina B. Gurrola, Xinsheng Zhu, Héctor H. Valdivia
    Pages 191-200
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Keywords

About this book

Drs. Xander Wehrens and Andrew Marks have gathered the collected wisdom of scientists that have devoted their working lives to the study of ryanodine receptors. In this series of brief, but informative, chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology. The book ends with several chapters on mutations in the receptor that causes disease and their role in adaptation to disease. There are interesting new developments in the control of ryanodine receptors by accessory proteins, the latest of which is the proposed role of leaky RyR channels in causing delayed after depolarizations, a cause of lethal ventricular arrhythmias. The series of reviews in Ryanodine Receptors: Structure, Function and Dysfunction in Clinical Disease will bring anyone rapidly up to speed in current progress in the field, as well as highlight remaining questions.

David E. Clapham, MD, PhD
Professor of Neurobiology and Pediatrics
Harvard Medical School

Editors and Affiliations

  • Dept. of Physiology and Cellular Biophysics, Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, USA

    Xander H. T. Wehrens, Andrew R. Marks

Bibliographic Information

  • Book Title: Ryanodine Receptors

  • Book Subtitle: Structure, function and dysfunction in clinical disease

  • Editors: Xander H. T. Wehrens, Andrew R. Marks

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/b100805

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag US 2005

  • Hardcover ISBN: 978-0-387-23187-7Published: 09 November 2004

  • Softcover ISBN: 978-1-4614-9840-7Published: 01 December 2014

  • eBook ISBN: 978-0-387-23188-4Published: 16 January 2006

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: XXI, 330

  • Topics: Cardiology

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