Genetics and Auditory Disorders

1. Front Matter

   Pages i-xii

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2. Introduction and Overview: Genetics in Auditory Science and Clinical Audiology

   • Bronya J. B. Keats, Charles I. Berlin

   Pages 1-22

3. Genes and Mutations in Hearing Impairment

   • Karen B. Avraham, Tama Hasson

   Pages 23-44

4. Mapping and Cloning of Genes for Inherited Hearing Impairment

   • Robert F. Mueller, Guy Van Camp, Nick J. Lench

   Pages 45-66

5. Genetic Epidemiology of Deafness

   • Walter E. Nance, Arti Pandya

   Pages 67-91

6. Cytogenetics and Cochlear Expressed Sequence Tags (ESTs) for Identification of Genes Involved in Hearing and Deafness

   • Anne B. Skvorak Giersch, Cynthia C. Morton

   Pages 92-120

7. Autosomal and X-Linked Auditory Disorders

   • Andrew J. Griffith, Thomas B. Friedman

   Pages 121-227

8. Hearing Loss and Mitochondrial DNA Mutations: Clinical Implications and Biological Lessons

   • Nathan Fischel-Ghodsian

   Pages 228-246

9. Mice as Models for Human Hereditary Deafness

   • Karen P. Steel, Alexandra Erven, Amy E. Kiernan

   Pages 247-296

10. Genetic Counseling for Deafness

    • Kathleen S. Arnos, M. Katherine Oelrich

    Pages 297-314

11. Back Matter

    Pages 315-322

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Genetics is fundamental to hearing function, and an understanding of genetics enhances both auditory research and the clinical treatment of the hearing impaired. Approaches to the diagnosis and treatment of hearing impairment have developed from technological advances in genetic research. This volume covers gene expression, mutations, mapping and cloning, as well as mitochondrial and cellular genetics. Chapters are also included on the uses of mouse models, genetic epidemiology and genetic counseling specifically for hearing impairment. As a comprehensive review of the genetics of hearing, this book will interest hearing researchers, clinicians and genetic counselors.

• DNA
• gene expression
• genes
• genetic research
• genetics
• hearing

From the reviews:

"This handbook represents one of the more recent additions to the expanding list of contributions arising from Springer, illuminating progress in auditory research. … this is an excellent and authoritative description of the state of the art in human auditory genetics. This area is moving so fast and, hence I recommend interested readers to get it now … ." (R. C. Trembath, Human Genetics, Vol. 114 (3), 2004)

• Department of Biometry and Genetics, Louisiana State University, New Orleans, USA

  Bronya J. B. Keats

• Department of Psychology and Parmly Hearing Institute, Loyola University of Chicago, Chicago, USA

  Richard R. Fay

• Department of Biology and Neuroscience and Cognitive Science Program, University of Maryland, College Park, USA

  Arthur N. Popper

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