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  • © 2009

Thrombin

Physiology and Disease

  • Stimulate interest in new targets of drug development and increase our present day understanding of the multiplicity of roles endowed to thrombin through the evolutionary process

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xii
  2. Thrombin: Structure, Functions, and Regulation

    • Enrico Di Cera*, Andras Gruber
    Pages 1-18
  3. Thrombin: To PAR or Not to PAR, and the Regulation of Inflammation

    • Rithwik Ramachandran, Mahmoud El-Daly, Mahmoud Saifeddine, Morley D. Hollenberg*
    Pages 19-46
  4. The Role of Thrombin in Vascular Development

    • Martin Moser, Cam Patterson*
    Pages 81-92
  5. The Role of Thrombin in Angiogenesis

    • Nikos E. Tsopanoglou*, Michael E. Maragoudakis
    Pages 93-113
  6. Thrombin and Thrombin Peptides in Wound Healing and Tissue Repair

    • Barbara Olszewska-Pazdrak, John S. Bergmann, Gerald M. Fuller, Darrell H. Carney
    Pages 115-132
  7. The Role of Thrombin and Thrombin Receptors in the Brain

    • Weibo Luo, Yingfei Wang, Georg Reiser*
    Pages 133-159
  8. The Role of Thrombin in Tumor Biology

    • Boris Kobrinsky*, Simon Karpatkin*
    Pages 161-172
  9. The Role of Thrombin and its Receptors in Epithelial Malignancies: Lessons from a Transgenic Mouse Model and Transcriptional Regulation

    • Zaidoun Salah, Sorina Grisaru-Granovsky, Myriam Maoz, Beatrice Uziely, Irit Cohen, Hagit Turm et al.
    Pages 173-188
  10. Anti-thrombotic Therapy in Cancer Patients

    • Gloria A. Petralia*, Ajay K. Kakkar
    Pages 189-203
  11. Thrombin Receptor Modulators: Medicinal Chemistry, Biological Evaluation, and Clinical Application

    • Cailin Chen*, Bruce E. Maryanoff*, Patricia Andrade-Gordon
    Pages 205-236
  12. Back Matter

    Pages 259-266

About this book

In addition to its central role in blood coagulation, it has become increasingly apparent that thrombin and thrombin receptors are involved in many other physiological processes and can contribute to a variety of disease states such as tumor progression and metastasis, inflammation, neurological disorders and cardiovascular complications. This book is a collection of reviews of up-to-date information on the above topics by leaders in these fields.

This book will be of value to researchers and academic professionals both in basic and clinical science who are interested in the fields of biochemistry, biophysics, cell biology, pharmacology, cancer, inflammation, angiogenesis, cardiovascular system and neuronal system. These areas of research are prime target areas for drug development by many pharmaceutical and biotechnology companies.

Editors and Affiliations

  • Medical School, University of Patras, Patras, Greece

    Michael E. Maragoudakis, Nikos E. Tsopanoglou

Bibliographic Information

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access