Glutamate Receptors in Peripheral Tissue

1. Front Matter

   Pages i-xv

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2. General Concepts

   1. Front Matter

      Pages 1-1

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   2. Glutamate Receptors in Peripheral Tissues: Distribution and Implications for Toxicology

      • Santokh Gill, Olga Pulido

      Pages 3-26

   3. Glutamate Receptor Pharmacology: Lessons Learned from the Last Decade of Stroke Trials

      • Daniel L. Small, Joseph S. Tauskela

      Pages 27-45

   4. Expression of Non-Organelle Glutamate Transporters to Support Peripheral Tissue Function

      • James C. Matthews

      Pages 47-75

   5. Anticancer Effects of Glutamate Antagonists

      • Wojciech Rzeski, Lechoslaw Turski, Chrysanthy Ikonomidou

      Pages 77-85

   6. Glutamate Receptors and their Role in Acute and Inflammatory Pain

      • Susan M. Carlton

      Pages 87-96

3. Specific Target Tissues, Organs, and Systems

   1. Front Matter

      Pages 97-97

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   2. The Vertebrate Retina

      • Victoria P. Connaughton

      Pages 99-127

   3. Glutamate Receptors in Taste Receptor Cells

      • Albertino Bigiani

      Pages 129-145

   4. Glutamate Receptors in Endocrine Tissues

      • Tania F. Gendron, Paul Morley

      Pages 147-168

   5. Adrenal Glutamate Receptors: A Role in Stress and Drug Addiction?

      • Daniela Jezova, Marek Schwendt

      Pages 169-178

   6. Glutamate Receptors in the Stomach and their Implications

      • Li Hsueh Tsai, Jang-yen Wu

      Pages 179-190

   7. Glutamate Toxicity in Lung and Airway Disease

      • Sami I. Said

      Pages 191-196

   8. Glutamate: Teaching Old Bones New Tricks—Implications for Skeletal Biology

      • Gary J. Spencer, Ian S. Hitchcock, Paul G. Genever

      Pages 197-209

   9. Expression and Function of Metabotropic Glutamate Receptors in Liver

      • Marianna Storto, Maria Pia Vairetti, Francesc X. Sureda, Barbara Riozzi, Valeria Bruno, Ferdinando Nicoletti

      Pages 211-217

   10. Neuroexcitatory Signaling in Immune Tissues

       • Helga S. Haas, Konrad Schauenstein

       Pages 219-232

   11. Platelet Glutamate Receptors as a Window into Psychiatric Disorders

       • Michael Berk

       Pages 233-241

4. Non-Mammalian Organisms

   1. Front Matter

      Pages 243-243

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   2. Analysis of Glutamate Receptor Genes in Plants: Progress and Prospects

      • Joanna C. Chiu, Eric D. Brenner, Rob DeSalle, Nora M. Barboza, Gloria M. Coruzzi

      Pages 245-255

Glutamate receptors (GluRs) in the central nervous system have been the subject of intense investigations for several decades, providing new avenues for the understanding of excitatory neurotransmission, excitotoxicity, mechanisms of injury, and therapeutics for several acute neurological conditions, such as brain trauma, and for neurodegenerative and neuropsychiatric disorders including addictions, Alzheimer disease, etc. Evidences of GluRs beyond the central nervous system were first reported in the early 1990s. When the idea of this book was conceived, the knowledge, specificity, and functional significance of GluRs in peripheral tissues was still in its embryonic stage. From our perspective, the idea of GluRs in peripheral tissues arose from our research on seafood toxins (see Chapter 1), and has now been reinforced by the results of other scientists working in similar areas. In this book, we have invited some of the leading authorities in the field to summarize their findings and to provide a framework for further investigations. The book is divided into three sections— Part I is on general concepts and concentrates on the distribution and cell-specific localiza­ tion of glutamate receptors, their transporters, and the pharmacology in peripheral tissues and organs. Part II emphasizes the presence and implications of these receptors in specific target tissues, organs, and systems, including liver, lungs, endocrine tissues, bone, immune system, etc. Part III focuses on glutamate receptors in plants to illustrate their presence beyond the animal kingdom.

• Calcium
• biology
• brain
• cancer
• molecular biology
• neurons
• time

• Toxicology Research Division, HPFB, Health Canada, Ottawa, Canada

  Santokh Gill, Olga Pulido

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