Overview
Part of the book series: The Springer International Series in Engineering and Computer Science (SECS, volume 765)
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Table of contents (15 papers)
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Front Matter
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Mechanism-Based PK/PD
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Front Matter
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Pharmacometrics
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Front Matter
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Pharmacotherapy
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Front Matter
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Back Matter
Keywords
About this book
This book contains chapters by leading researchers in pharmacokinetic/pharmacodynamic modeling and will be of interest to anyone involved with the application of pharmacokinetic and pharmacodynamics to drug development.
The use of mathematical modeling and associated computational methods is central to the study of the absorption, distribution and elimination of therapeutic drugs (pharmacokinetics) and to understanding how drugs produce their effects (pharmacodynamics). From its inception, the field of pharmacokinetics and pharmacodynamics has incorporated methods of mathematical modeling, simulation and computation in an effort to better understand and quantify the processes of uptake, disposition and action of therapeutic drugs. These methods for pharmacokinetic/pharmacodynamic systems analysis impact all aspects of drug development. In vitro, animal and human testing, as well as drug therapy are all influenced by these methods. Modeling methodologies developed for studying pharmacokinetic/ pharmacodynamic processes confront many challenges. This is related in part to the severe restrictions on the number and type of measurements that are available from laboratory experiments and clinical trials, as well as the variability in the experiments and the uncertainty associated with the processes themselves.
The contributions are organized in three main areas: Mechanism-Based PK/PD, Pharmacometrics and Pharmacotherapy. Both professionals and academics will profit from this extensive work.
Editors and Affiliations
Bibliographic Information
Book Title: Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
Editors: David Z. D’Argenio
Series Title: The Springer International Series in Engineering and Computer Science
DOI: https://doi.org/10.1007/b105246
Publisher: Springer New York, NY
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eBook Packages: Springer Book Archive
Copyright Information: Springer Science+Business Media New York 2004
Hardcover ISBN: 978-1-4020-7804-0Published: 31 March 2004
Softcover ISBN: 978-1-4757-8562-3Published: 14 April 2013
eBook ISBN: 978-0-306-48523-7Published: 18 April 2006
Series ISSN: 0893-3405
Edition Number: 1
Number of Pages: VII, 318
Topics: Pharmacology/Toxicology, Statistics for Life Sciences, Medicine, Health Sciences, The Computing Profession, Biomedical Engineering and Bioengineering