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Dipeptidyl Aminopeptidases in Health and Disease

  • Book
  • © 2003

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Editors:
  1. Nathan Back

    1. State University of New York at Buffalo, USA

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  2. Irun R. Cohen

    1. The Weizmann Institute of Science, Israel

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  3. David Kritchevsky

    1. Wistar Institute, USA

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  4. Abel Lajtha

    1. N.S. Kline Institute for Psychiatric Research, USA

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  5. Rodolfo Paoletti

    1. University of Milan, Italy

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 524)

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Table of contents (42 chapters)

  1. Front Matter

    Pages i-xxxii
    Download chapter PDF

  2. Structure and Function of Dipeptidyl Aminopeptidases

    1. Dipeptidyl Peptidase IV Substrates

      • Ingrid De Meester, Anne-Marie Lambeir, Paul Proost, Simon Scharpé
      Pages 3-17

    2. Structure-Function Relationship of DPP IV: Insights into its Dimerisation and Gelatinase Activity

      • Oliver Baum, Werner Reutter, Felix Bermpohl
      Pages 19-27

    3. Exploration of the Active Site of Dipeptidyl Peptidase IV From Porphyromonas gingivalis

      • Anne-Marie Lambeir, Dean Rea, Vilmos Fülö, Yumi Kumagai, Koen Augustyns, Ingrid De Meester et al.
      Pages 29-35

    4. Modification of the Biological Activity of Chemokines by Dipeptidyl Peptidase IV — a Side Effect in the Use of Inhibitors?

      • Rolf Mentlein, Florian Schiemann, Andreas Ludwig, Ernst Brandt
      Pages 37-47

    5. Molecular Chimeras and Mutational Analysis in the Prolyl Oligopeptidase Gene Family

      • Katerina Ajami, Catherine A. Abbott, Vanessa Gysbers, Thilo Kähne, Geoffrey W. McCaughan, Mark D. Gorrell
      Pages 49-55

    6. The Specificity of DP IV for Natural Substrates is Peptide Structure Determined

      • Kerstin Kühn-Wache, Torsten Hoffmann, Susanne Manhart, W. Brandt, Hans-Ulrich Demuth
      Pages 57-63

    7. New Results on the Conformations of Potent DP IV (CD26) Inhibitors bearing the N-terminal MWP Structural Motif

      • Carmen Mrestani-Klaus, Wolfgang Brandt, Jürgen Faust, Sabine Wrenger, Dirk Reinhold, Siegfried Ansorge et al.
      Pages 65-68

    8. Different Inhibition Mechanisms of Dipeptidyl Peptidase IV by Tryptophan Containing Peptides and Amides

      • Angela Stöckel-Maschek, Beate Stiebitz, Jürgen Faust, Ilona Born, Thilo Kähne, Mark D. Gorrell et al.
      Pages 69-72

    9. Re-Uptake Mechanisms of Peptide Fragments after DPP IV-Mediated Proteolysis in the Peripheral Nervous System

      • Q. Thai Dinh, Christian Peiser, Axel Fischer, David A. Groneberg
      Pages 73-76

  3. DPP IV-Like Enzymes

    1. Dipeptidyl Peptidase IV Gene Family

      • Tong Chen, Katerina Ajami, Geoffrey W. McCaughan, Mark D. Gorrell, Catherine A. Abbott
      Pages 79-86

    2. Seprase-DPPIV Association and Prolyl Peptidase and Gelatinase Activities of the Protease Complex

      • G. Ghersi, H. Dong, L.A. Goldstein, Y. Yeh, L. Hakkinen, H.S. Larjava et al.
      Pages 87-94

    3. Dipeptidyl Peptidase-IV Activity and/or Structure Homologues (DASH) in Transformed Neuroectodermal Cells

      • Radek Malík, Petr Bušek, Vladislav Mareš, Jan Ševčík, Zdeněk Kleibl, Aleksi Šedo
      Pages 95-102

    4. Characterisation of Human DP IV Produced by a Pichia pastoris Expression System

      • Joachim W. Baer, Bernd Gerhartz, Torsten Hoffmann, Fred Rosche, Hans-Ulrich Demuth
      Pages 103-108

    5. Isolation and Characterization of Attractin-2

      • Daniel Friedrich, Kerstin Kühn-Wache, Torsten Hoffmann, Hans-Ulrich Demuth
      Pages 109-113

    6. Investigation of DP IV-dependent Protein-Protein Interactions using Surface Plasmon Resonance

      • Joerg Stork, Torsten Hoffmann, Hans-Ulrich Demuth
      Pages 115-119

  4. Immune Mechanisms and Immune Disorders

    1. Synergistic Action of DPIV and APN in the Regulation of T Cell Function

      • Uwe Lendeckel, Marco Arndt, Alicja Bukowska, Janine Tadje, Carmen Wolke, Thilo Kähne et al.
      Pages 123-131

    2. CD26/DPP IV in Experimental and Clinical Organ Transplantation

      • Stephan Korom, Ingrid De Meester, A. Belyaev, Georg Schmidbauer, Konrad Schwemmle
      Pages 133-143

    3. CD26 is Involved in the Regulation of T-Cell Plasma Membrane Compartmentation

      • Juan Lojo, Francisco J. Salgado, Montserrat Nogueira, Oscar J. Cordero
      Pages 145-153

    4. Inhibition of Dipeptidylpeptidase IV (DPP IV, CD26) Activity Modulates Surface Expression of CTLA-4 in Stress-Induced Abortions

      • Jens Rüter, Hans-Ulrich Demuth, Petra C. Arck, Torsten Hofmann, Burghard F. Klapp, Martin Hildebrandt
      Pages 155-163
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Keywords

About this book

Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany.

Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes.

Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics:

- Structure and function of dipeptidyl aminopeptidases,
- DPP IV-like proteins,
- Immune mechanisms and immune disorders,
- Cancer and angiogenesis,
- Diabetes and metabolism,
- Therapeutic implications.

Editors and Affiliations

  • State University of New York at Buffalo, USA

    Nathan Back

  • The Weizmann Institute of Science, Israel

    Irun R. Cohen

  • Wistar Institute, USA

    David Kritchevsky

  • N.S. Kline Institute for Psychiatric Research, USA

    Abel Lajtha

  • University of Milan, Italy

    Rodolfo Paoletti

Bibliographic Information

  • Book Title: Dipeptidyl Aminopeptidases in Health and Disease

  • Editors: Nathan Back, Irun R. Cohen, David Kritchevsky, Abel Lajtha, Rodolfo Paoletti

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/b105297

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2003

  • Hardcover ISBN: 978-0-306-47717-1Published: 31 March 2003

  • Softcover ISBN: 978-1-4757-8730-6Published: 28 April 2013

  • eBook ISBN: 978-0-306-47920-5Published: 11 April 2006

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XXXII, 359

  • Number of Illustrations: 72 b/w illustrations

  • Topics: Immunology, Pharmacy, Internal Medicine, Biochemistry, general

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