TxNxM1

1. Front Matter

   Pages i-ix

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2. The Metastasis and its Primary

   1. Front Matter

      Pages xi-xi

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   2. Introduction

      Pages 1-2

   3. Metastases to the Thorax

      Pages 3-53

   4. Metastases to the Abdominal Organs

      Pages 54-79

   5. Metastases to the Digestive Tract

      Pages 80-104

   6. Metastases to the Urogenital System

      Pages 105-128

   7. Metastases to the Central Nervous System

      Pages 129-178

   8. Metastases to the Head and Neck

      Pages 179-208

   9. Metastases to the Skin, Soft-Tissues and Bone

      Pages 209-266

3. The Primary and its Metastases

   1. Front Matter

      Pages 267-267

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   2. Metastases from Thoracic Tumors

      Pages 269-365

   3. Metastases from Tumors of the Digestive Tract

      Pages 366-412

   4. Metastases from Cancers of the Abdominal Organs

      Pages 413-455

   5. Metastases from Cancers of the Urogenital Tract

      Pages 456-579

   6. Metastases from Tumors of the Central Nervous System

      Pages 580-607

   7. Metastases from Tumors of the Head and Neck

      Pages 608-673

   8. Metastases from Tumors of the Skin, Soft-Tissue and Bone

      Pages 674-741

4. Back Matter

   Pages 742-757

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Although distant metastases are the most dreaded situation in the evolution of cancer of every organ, the medical literature has surprisingly given little attention to the anatomical relationship between the primary tumor and metastasic sites. Only risk factors, treatment possibilities, and survival results are extensively examined.
Stimulated by the occurrence in his practice of some puzzling and unexpected metastases, the author reviewed more than 12,000 references. He looked for anatomical relationships highlighting the relation between the location of the primary tumors and the particular patterns of metastasis observed. It would seem that the `pathways and flows' are apparently a more decisive factor in the implantation of the metastases than the `seed and soil' properties of the cancer cells and the metastatic site.
Aided by his colleague Dr. T. Geukens, M.D., the author includes original anatomical drawings, illustrating the sometimes unexpected pathways the cancer cells follow in order to reach the organs where they will become lodged and give rise to metastatic tumors. The subject has apparently not been exhausted in the literature and several ideas are given for further research.

• Tumor
• anatomy
• cancer
• implant
• metastasis
• treatment

"This book will be of value to those learning about malignant disease and wanting to gain insight into the patterns of spread of primary malignancies. In addition, the first part of the book is useful in reviewing the likely origins of metastatic disease in the various sites. It provides a wealth of information and references on the subject of metastatic disease and would be a useful addition to the library of any department dealing with the diagnosis, investigation and treatment of malignant disease."
(Mr P. Allan, Royal Infirmary, Edinburgh)

Dr. J.M. Debois is a retired radiation oncologist with forty years of academic and private practice. He has published two other books and more than a hundred articles, of which several appeared in peer-reviewed periodicals, case reports and reviews.

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