Annual Reports in Combinatorial Chemistry and Molecular Diversity

1. Front Matter

   Pages i-xiii

   PDF

2. Combinatorial Chemistry

   1. Front Matter

      Pages 1-1

      PDF

   2. Combinatorial chemistry: A perspective

      • Michael R. Pavia

      Pages 3-5

   3. Techniques for mixture synthesis

      • John S. Kiely

      Pages 6-18

   4. Techniques for single-compound synthesis

      • Sepehr Sarshar, Adnan M. M. Mjalli

      Pages 19-29

   5. Recent advances in solid-phase synthesis

      • Steven E. Hall

      Pages 30-40

   6. Selection of supports for solid-phase organic synthesis

      • Irving Sucholeiki

      Pages 41-49

   7. Solution-phase combinatorial chemistry

      • Diane M. Coe, Richard Storer

      Pages 50-58

   8. Analytical methods for the quality control of combinatorial libraries

      • William L. Fitch

      Pages 59-68

   9. Automated synthesis

      • Sheila H. DeWitt

      Pages 69-77

   10. Applications of combinatorial technology to drug discovery

       • Dinesh V. Patel

       Pages 78-89

3. Combinatorial Biology and Evolution

   1. Front Matter

      Pages 91-91

      PDF

   2. Combinatorial biology and evolution: A perspective

      • Brian K. Kay, Andrew D. Ellington

      Pages 93-94

   3. Models and search strategies for applied molecular evolution

      • Bennett Levitan

      Pages 95-152

   4. Molecular evolutionary biology

      • Peter Schuster

      Pages 153-168

   5. Landscapes for molecular evolution: Lessons from in vitro selection experiments with nucleic acids

      • Sulay D. Jhaveri, Ichiro Hirao, Sabine Bell, Kyle W. Uphoff, Andrew D. Ellington

      Pages 169-191

   6. Synthetic peptide libraries

      • Zhan-Gong Zhao, Kit S. Lam

      Pages 192-209

   7. Phage display

      • John Collins

      Pages 210-262

4. Informatics and Related Topics

   1. Front Matter

      Pages 263-263

      PDF

   2. Informatics and related topics: A perspective

      • Walter H. Moos

      Pages 265-266

Combinatorial chemistry and molecular diversity approaches to scientific inquiry and novel product R&D have exploded in the 1990s! For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed, more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research.
This first volume covers: (i) combinatorial chemistry, (ii) combinatorial biology and evolution, and (iii) informatics and related topics. Within each section chapters are prepared by experts in the field, including, for example, in Section I: Coverage of mixture pools vs. parallel individual compound synthesis, solution vs. solid-phase synthesis, analytical tools, and automation. Section II highlights selection strategies and library-based evolution, phage display, peptide and nucleic acid libraries. Section III covers databases and library design, high through-put screening, coding strategies vs. deconvolutions, intellectual property issues, deals and collaborations, and successes to date.

• Compound
• biology
• chemistry
• drug discovery
• mutation
• nucleic acid
• organic synthesis
• pharmaceutical
• synthesis

• MitoKor, San Diego, USA

  W. H. Moos

• Sphinx Pharmaceuticals, Cambridge, USA

  M. R. Pavia

• University of North Carolina, Chapel Hill, USA

  B. K. Kay

• Indiana University, Bloomington, USA

  A. D. Ellington

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