Cancer Cell Lines Part 2

1. Front Matter

   Pages i-x

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2. Ovarian Cancer

   • Anne P. Wilson, Chris M. Garner

   Pages 1-53

3. Cervical Cancer

   • Swee Y. Sharp, Lloyd R. Kelland

   Pages 55-70

4. Endometrial Cancer

   • P. G. Satyaswaroop

   Pages 71-78

5. Breast Cancer

   • Robert L. Sutherland, Colin K. W. Watts, Christine S. L. Lee, Elizabeth A. Musgrove

   Pages 79-106

6. Paired Breast Cancer Cell Lines

   • Ignacio I. Wistuba, Arvind K. Virman, Adi E Gazdar

   Pages 107-119

7. Ovarian Germ Cell Tumors

   • Masumi Sawada, Tsuneharu Miki

   Pages 121-125

8. Testicular Germ Cell Tumors

   • Martin F. Pera

   Pages 127-140

9. Choriocarcinoma

   • Vadivel Ganapathy, Puttur D. Prasad, Frederick H. Leibach

   Pages 141-147

10. Thymomas and Thymic Cancers

    • H. K. Müller-Hermelink, Alexander Marx

    Pages 149-155

11. Kaposi’s Sarcoma

    • Christopher Boshoff

    Pages 157-166

12. Brain Tumors

    • Francis Ali-Osman

    Pages 167-184

13. Head and Neck Cancers

    • Christopher D. Lansford, Reidar Grenman, Henning Bier, Kenneth D. Somers, Sang Yoon Kim, Theresa L. Whiteside et al.

    Pages 185-255

14. Gastric Cancer

    • Toshimitsu Suzuki, Morimasa Sekiguchi

    Pages 257-291

15. Colorectal Cancer

    • Michael G. Brattain, J. K. V. Willson, A. Koterba, S. Patil, S. Venkateswarlu

    Pages 293-303

16. Prostate Cancer

    • James M. Kozlowski, Julia A. Sensibar

    Pages 305-331

17. Liver Cancer

    • Masayoshi Namba, Masahiro Miyazaki, Kenichi Fukaya

    Pages 333-343

18. Wilms’ Tumor and Other Childhood Renal Neoplasms

    • Noel A. Brownlee, Gian G. Re, Debra J. Hazen-Martin

    Pages 345-359

19. Retinoblastoma

    • Brenda L. Gallie, Judy Trogadis, Liping Han

    Pages 361-374

20. Back Matter

    Pages 375-377

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Continuous cell lines derived from human cancers are the mostwidely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions offundamental importance to the relevanceof human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative oftumors at that site is naïve and misleading.

• biology
• brain tumors
• breast cancer
• cancer
• cancer research
• carcinoma
• cell
• cell lines
• gastric cancer
• immunology
• liver
• ovarian cancer
• tumor
• tumors

• University College London, London, UK

  John R. W. Masters

• Dept. of Bioengineering, University of California San Diego, USA

  Bernhard Palsson

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