Skip to main content
SpringerLink
Log in
Book cover

Role of Proteases in the Pathophysiology of Neurodegenerative Diseases

  • Book
  • © 2002

Overview

Editors:
  1. Abel Lajtha

    1. Nathan S. Kline Institute for Psychiatric Research, Orangeburg

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Naren L. Banik

    1. Medical University of South Carolina, Charleston

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (18 chapters)

  1. Front Matter

    Pages ii-xii
    Download chapter PDF

  2. The Role of Proteolytic Eenzymes in Autoimmune Demyelinating Diseases: An Update

    • Marion Smith
    Pages 1-4

  3. Proteases in Demyelination

    • M.L. Cuzner
    Pages 5-23

  4. Calcium Activated Neutral Proteinase in Demyelinating Diseases

    • Donald C. Shields, Naren L. Banik
    Pages 25-45

  5. Papain-like Cysteine Proteases and Their Implications in Neurodegenerative Diseases

    • Dieter Brömme, Suzana Petanceska
    Pages 47-61

  6. The Role of the Calpain System in Neuromuscular Disease

    • Darrel E. Goll, Valery F. Thompson, Hongqi Li, Jinyang Cong
    Pages 63-73

  7. The Role of Calpain Proteolysis in Cerebral ischemia

    • Dwaine F. Emerich, Raymond T. Bartus
    Pages 75-84

  8. Calpain Isoforms in the Eye

    • T.R. Shearer, H. Ma, M Shih, K.J. Lampi, C. Fukiage, M. Azuma
    Pages 85-99

  9. Metalloendopeptidase EC 3.4.24.15 in Neurodegeneration

    • Carmela R. Abraham, Franchot Slot
    Pages 101-116

  10. Cysteine Proteases, Synaptic Degeneration and Neuroodegenerative Disorders

    • Mark P. Mattson, Sic L. Chan
    Pages 117-135

  11. The Ubiquitin/Proteasome Pathway in Neurological Disorders

    • Maria E. Figueiredo-Pereira, Patricia Rockwell
    Pages 137-153

  12. Amyloid (Tace, Bace) and Presenilin Proteases Associated with Alzheimer’s Disease

    • Neville Marks, Martin J. Berg
    Pages 155-178

  13. Caspases in Neurodegeneration

    • Jörg B. Schulz, Michael A. Moskowitz
    Pages 179-187

  14. Therapeutic Approaches with Protease Inhibitors in Neurodegenerative and Neurological Diseases

    • Kevin K.W. Wang
    Pages 189-197

  15. Pathophysiology of Central Nervpis System Trauma: Proteolytic Mechanisms and Related Therapeutic Approaches

    • Swapan K. Ray, Denise C. Matzelle, Gloria G. Wilford, Lawrence F. Eng, Edward L. Hogan, Naren L. Banik
    Pages 199-226

  16. Lysosomal Cysteine Proteases and Their Protein Inhibitor

    • Vito Turk, Janko Kos, Gregor Guncar, Boris Turk
    Pages 227-240

  17. Proteases and Their Inhibitors in Gliomas

    • Peter A. Forsyth, Dylan R. Edwards, Marc A. LaFleur, V. W. Yong
    Pages 241-268

  18. Proteolysis of Mutant Gene Products are Key Mechanisms in Neurodegenerative Diseases

    • Vivian Y.H. Hook
    Pages 269-282

  19. Mammalian Proteinase Genes

    • Hahn-Jun Lee, Koichi Suzuki, Takaomi C Saido
    Pages 283-296

  20. Back Matter

    Pages 297-302
    Download chapter PDF
Back to top

Keywords

About this book

Researchers seeking problems that offer more hope of success often avoid subjects that seem to be difficult to approach experimentally, or subjects for which experimental results are difficult to interpret. The breakdown part of protein turnover in vivo, particularly in nervous tissue, was such a subject in the past – it was difficult to measure and difficult to explore the mechanisms involved. For factors that influence protein metabolism, it was thought that protein content, function, and distribution are controlled only by the synthetic mechanisms that can supply the needed specificity and response to stimuli. The role of breakdown was thought to be only a general metabolic digestion, elimination of excess polypeptides. We now know that the role of breakdown is much more complex: it has multiple functions, it is coupled to turnover, and it can affect protein composition, function, and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions: it serves to activate and inactivate enzymes, modulate membrane function, alter receptor channel properties, affect transcription and cell cycle, form active peptides, and much more. The hydrolysis of peptide bonds often involves multiple steps, many enzymes, and cycles (such as ubiquination), and often requires the activity of enzyme complexes. Their activation, modification, and inactivation can thus play an important role in biological functions, with numerous families of proteases participating. The specific role of each remains to be elucidated.

Editors and Affiliations

  • Nathan S. Kline Institute for Psychiatric Research, Orangeburg

    Abel Lajtha

  • Medical University of South Carolina, Charleston

    Naren L. Banik

About the editors

Dr. Lajtha is the editor of the Journal of Neurochemical Research.

Bibliographic Information

  • Book Title: Role of Proteases in the Pathophysiology of Neurodegenerative Diseases

  • Editors: Abel Lajtha, Naren L. Banik

  • DOI: https://doi.org/10.1007/b111075

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2002

  • Hardcover ISBN: 978-0-306-46579-6Published: 31 July 2001

  • Softcover ISBN: 978-1-4419-3360-7Published: 01 December 2010

  • eBook ISBN: 978-0-306-46847-6Published: 08 May 2007

  • Edition Number: 1

  • Number of Pages: XIV, 302

  • Topics: Neurosciences, Neurology

Publish with us

Policies and ethics

Back to top

Search

Navigation