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  • © 2002

Biology of the Mammary Gland

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 480)

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Table of contents (35 chapters)

  1. Front Matter

    Pages i-xiv
  2. Fibroblast Growth Factor Signalling and Cyclin D1 Function are Necessary for Normal Mammary Gland Development during Pregnancy

    • Vera Fantl, Anna Creer, Christian Dillon, Janine Bresnick, David Jackson, Paul Edwards et al.
    Pages 1-7
  3. Hepatocyte Growth Factor and Neuregulin in Mammary Gland Cell Morphogenesis

    • Catherin Niemann, 1,2Volker Brinkmann, Walter Birchmeier
    Pages 9-18
  4. Expression and Localization of Growth Factors during Mammary Gland Development

    • Fred Sinowatz, Sabine Kölle, Dieter Schams, Annette Plath
    Pages 19-25
  5. Insulin-like Growth Factor Binding Protein-5 (IGFBP-5) Potentially Regulates Programmed Cell Death and Plasminogen Activation in the Mammary Gland

    • Elizabeth Tonner, Gordon Allan, Lulzim Shkreta, John Webster, C. Bruce, A. Whitelaw et al.
    Pages 45-53
  6. Somatostatin and Opioid Receptors in Mammary Tissue

    • Anastassia Hatzoglou, Efstathia Bakogeorgou, Marillena Kampa, Simone Panagiotou, Pierre-Marie Martin, Spyros Loukas et al.
    Pages 55-63
  7. Heparan Sulphate

    • Kirsty L. Bateman, Maryse Delehedde, Nicolas Sergeant, Isabelle Wartelle, Rishma Vidyasagar, David G. Fernig
    Pages 65-69
  8. Progestin-induced Mammary Growth Hormone (GH) Production

    • Jan A. Mol, Irma Lantinga- van Leeuwen, Evert van Garderen, Ad Rijnberk
    Pages 71-76
  9. Translocation and Action of Polypeptide Hormones within the Nucleus

    • Charles V. Clevenger, Michael A. Rycyzyn
    Pages 77-84
  10. Mammary Gland Development and the Prolactin Receptor

    • Nadine Binart, Christopher J. Ormandy, Paul A. Kelly
    Pages 85-92
  11. Paracrine Mechanisms of Mouse Mammary Ductal Growth

    • G. R. Cunha, J. F. Wiesen, Z. Werb, P. Young, Y. K. Hom, P. S. Cooke et al.
    Pages 93-97
  12. Targeting of PKA in Mammary Epithelial Cells

    • Roger A. Clegg, Rachel A. Gardner, Rushika N. Sumathipala, Françoise Lavialle, Raphaël Boisgard, Michéle Ollivier-Bousquet
    Pages 99-105
  13. The PEA3 Group of ETS-related Transcription Factors

    • Yvan de Launoit, Anne Chotteau-Lelievre, Claude Beaudoin, Laurent Coutte, Sonia Netzer, Carmen Brenner et al.
    Pages 107-116
  14. Transcription Factor NF 1 Expression in Involuting Mammary Gland

    • Rosemary Kane, Darren Finlay, Teresa Lamb, Finian Martin
    Pages 117-122
  15. The Elf Group of Ets-Related Transcription Factors

    • Ross S. Thomas, Annie N.Y. Ng, Jiong Zhou, Martin J. Tymms, Wolfgang Doppler, Ismail Kola
    Pages 123-128
  16. The Role of Stat3 in Apoptosis and Mammary Gland Involution

    • Rachel S Chapman, Paula Lourenco, Elizabeth Tonner, David Flint, Stefan Selbert, Kyoshi Takeda et al.
    Pages 129-138
  17. Nucleosome Organisation of the β-Lactoglobulin Gene

    • C. Bruce A. Whitelaw
    Pages 147-153
  18. Chromatin Remodeling in Hormone-Dependent and - Independent Breast Cancer Cell Lines

    • Claire Giamarchi, Catherine Chailleux, Hùløne Richard-Foy
    Pages 155-161

About this book

Proceedings of the European Cooperation in the Field of Scientific and Technical Research (COST 825) Symposium on Mammary Gland Biology, held September 16-18, 1999, in Tours, France.
It is difficult to overstate the evolutionary and functional significance of mammary tissue in biology. Substantial progress has been made by researchers in various disciplines, particularly over the last fifteen years, towards realizing the potential of this tissue to yield powerful experimental models for morphogenesis and tissue development; for cellular differentiation; for the biosynthesis and secretion of proteins, lipids, small molecules and inorganic salts; and for the coordination and regulation of these processes. More recently, the possibility of exploiting the secretory epithelial cells of mammary tissue as `cell factories' has become a reality and the recombinant production by lactating animals of an increasing number of proteins, valuable both in the pharmaceutical and `nutraceutical' fields, is in progress or under development.
Also in this sphere of agricultural production, genetic as well as nutritional technologies are under investigation and exploitation to optimize milk composition for various end-uses - for instance in food process and manufacture. The possibilities of deriving health benefit from the bioactive properties of some of the minor constituents of milk are emerging to counter the highly-publicized negative health impact of excessive consumption of saturated animal fats. In human nutrition and medicine, the mammary gland is both a source of nutrition to the neonate and a potential health threat to the adult female - breast cancer remains the major single cause of female mortality in most developed countries.
This volume provides a unique glimpse into our understanding, at the cutting edge of a variety of disciplines, of this versatile and extraordinary tissue, at the birth of the twenty-first century.

Reviews

`...this book represents one of the best of its kind. Each chapter represents and excellent point of well-referenced initial contact to the increasing number of funded investigators interested in the biology of the mammary gland.'
TRENDS in Endocrinology - Metabolism, 12:8(2001)

Editors and Affiliations

  • Utrecht University, Utrecht, The Netherlands

    Jan A. Mol

  • Hannah Research Institute, Ayr, Scotland, UK

    Roger A. Clegg

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access