Prostacyclin and Its Receptors

1. Front Matter

   Pages i-ix

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2. An introduction to prostacyclin and its receptors

   Pages 1-27

3. The development of prostacyclin analogues

   Pages 29-58

4. Nonprostanoid prostacyclin mimetics

   Pages 59-78

5. Isolation, cloning and characterisation of IP-receptors

   Pages 79-108

6. IP-receptors on platelets

   Pages 109-139

7. IP-receptors in the vasculature

   Pages 137-188

8. IP-receptors on neutrophils

   Pages 189-214

9. IP-receptors on monocytes/macrophages and lymphocytes

   Pages 215-242

10. IP-receptors on sensory neurones

    Pages 243-270

11. IP-receptors in the enteric nervous system

    Pages 271-284

12. IP-receptors in the central nervous system

    Pages 285-304

13. Back Matter

    Pages 305-310

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In addition to its well known anti-platelet and hypotensive properties, prostacyclin activates neuronal receptors in the central, enteric and sensory nervous systems. This volume discusses the properties of prostacyclin receptors in the cardiovascular and nervous systems, as well as in cells involved in inflammatory reactions. The chemistry and pharmacology of prostacyclin mimetics are also explored, higlighting their therapeutic value.

• Nervous System
• central nervous system
• chemistry
• pharmacology
• receptor

• The Chinese University of Hong Kong, Hong Kong SAR, China

  Helen Wise, Robert L. Jones

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