Herpesviruses and Immunity

1. Front Matter

   Pages i-xx

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2. Evasion and Obstruction

   • Patricia L. Ward, Bernard Roizman

   Pages 1-32

3. Immunopathology of Herpesvirus Infections

   • Barry T. Ruse, Sally S. Atherton

   Pages 33-51

4. HSV Gene Expression during Latent Infection and Reactivation

   • Edward K. Wagner, David C. Bloom

   Pages 53-77

5. T Cell Activation and Lymphokine Induction in Herpesvirus saimiri Immortalized Cells

   • Peter Geck

   Pages 79-114

6. Kaposi’s Sarcoma-Associated Herpesvirus (KSHV/HHV8) and the Etiology of KS

   • Sonja J. Olsen, Patrick S. Moore

   Pages 115-147

7. Immunobiology of Murine Gamma Herpesvirus-68

   • James P. Stewart, Edward J. Usherwood, Bernadette Dutia, Anthony A. Nash

   Pages 149-163

8. EBV and B Cell Lymphomas

   • George Klein

   Pages 165-190

9. Immune Responses to Epstein-Barr Viral Infection

   • Takeshi Sairenji, Takeshi Kurata

   Pages 191-206

10. EBV Persistence in Vivo

    • Davida Thorley-Lawson

    Pages 207-229

11. Epstein-Barr Virus Vaccines

    • Hans J. Wolf, Andrew J. Morgan

    Pages 231-246

12. Inhibition of MHC Class I Function by Cytomegalovirus

    • Hartmut Hengel, Ulrich H. Koszinowski

    Pages 247-264

13. Cell-Mediated Immunity against Varicella-Zoster Virus

    • Ann M. Arvin

    Pages 265-290

14. Complement Control Proteins of Rhadinoviruses

    • Jens-Christian Albrecht, Frank Neipel, Bernhard Fleckenstein

    Pages 291-308

15. Back Matter

    Pages 309-317

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Although virology and immunology are now considered separate disciplines, history shows that these areas ofinvestigation always overlapped and one cannot really exist without the other. This trend has become particularly significant and fruitful in the past few years in the area of herpesvirus research. The genomes of the most important herpesviruses have been sequenced, a significant portion of their genes have been identified, and many secrets of regulation of gene expr- sion have been unraveled. Now this progress sets the stage for a true revolution in herpesvirus research: analysis of interactions between the host and the virus. Because herpesviruses can induce, suppress, and fool the immune system, the most productive herpesvirologists are also expert immunologists, and the current results ofthis interdisciplinary effort are truly remarkable. Because herpesviruses cause many important human diseases, the devel- ment of vaccines against these agents is a very significant goal. This effort is also very challenging because of the complexity of herpesviruses and the lack of sufficient information about immune responses. The remarkable ability of herpesviruses to escape immune responses is - other feature that brings immunology and virology together. Herpesviruses - code many proteins that interact with and down-regulate some key elements of the immune system. Thisproperty of herpesviruses represents amajor challenge in developing strategies against these viruses. On the positive side, these viral proteins also provide novel tools for analyzing specific immune reactions and molecular mechanisms.

• immunobiology
• infection
• infections
• protein
• viral infection
• virus
• infectious diseases

• University of South Florida College of Medicine, Tampa

  Peter G. Medveczky, Herman Friedman

• University of Pisa, Pisa, Italy

  Mauro Bendinelli

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