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Genomics and Proteomics

Functional and Computational Aspects

  • Book
  • © 2002

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Editors:
  1. Sándor Suhai

    1. Deutsches Krebsforschungszentrum, Heidelberg, Germany

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-viii
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  2. ... and Counting

    • Jörg D. Hoheisel
    Pages 1-3

  3. Obtaining and Evaluating Gene Expression Profiles with cDNA Microarrays

    • Michael Bittner, Yidong Chen, Sally A. Amundson, Javed Khan, Albert J. Fornace Jr., Edward R. Dougherty et al.
    Pages 5-25

  4. Large Scale Expression Screening Identifies Molecular Pathways and Predicts Gene function

    • Nicolas Pollet, Volker Gawantka, Hajo Delius, Christof Niehrs
    Pages 27-35

  5. The Glean Machine

    • Daniel L. Hartl, E. Fidelma Boyd, Carlos D. Bustamante, Stanley A. Sawyer
    Pages 37-49

  6. Automatic Assembly and Editing of Genomic Data

    • B. Chevreux, T. Pfisterer, S. Suhai
    Pages 51-65

  7. Quest

    • William R. Taylor, Nigel P. Brown
    Pages 67-82

  8. An Essay on Individual Sequence Variation in Expressed Sequence Tags(ESTs)

    • Jens Reich, David Brett, Jens Hanke
    Pages 83-94

  9. Sequence Similarity Based Gene Prediction

    • Roderic Guigó, Moisés Burset, Pankaj Agarwal, Josep F. Abril, Randall F. Smith, James W. Fickett
    Pages 95-106

  10. Functional Proteomics

    • Joachim Klose
    Pages 107-120

  11. The Genome as a Flexible Polymer Chain

    • Jorg Langowski, Carsten Mehring, Markus Hammermann, Konstantin Klenin, Christian Munkel, Katalin Tóth et al.
    Pages 121-132

  12. Analysis of Chromosome Territory Architecture in the Human Cell Nucleus

    • H. Bornfleth, C. Cremer, T. Cremera, S. Dietzel, P. Edelmann, R. Eils et al.
    Pages 133-140

  13. From Sequence to Structure and Function

    • Jerome Baudry, Serge Crouzy, Benoit Roux, Jeremy C. Smith
    Pages 141-148

  14. Shox Homeobox Gene and Turner Syndrome

    • E. Rao, G. A. Rappold
    Pages 149-155

  15. A Feature-Based Approach to Discrimination and Prediction of Protein Folding

    • Boris Mirkin, Otto Ritter
    Pages 157-177

  16. Linking Structural Biology With Genome Research

    • Udo Heinemann, Juergen Frevert, Klaus-Peter Hofman, Gerd Illing, Hartmut Oschkinat, Wolfram Saenger et al.
    Pages 179-189

  17. G Protein-Coupled Receptors, or The Power of Data

    • Florence Horn, Mustapha Mokrane, Johnathon Weare, Gerrit Vrien
    Pages 191-214

  18. Distributed Application Management in Bioinformatics

    • M. Senger, P. Ernst, K. -H. Glatting
    Pages 215-229

  19. Is Human Genetics Becoming Dagerous to Society?

    • Charles J. Epstein
    Pages 231-242

  20. Back Matter

    Pages 243-250
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Keywords

About this book

Genome research will certainly be one of the most important and exciting sci- tific disciplines of the 21st century. Deciphering the structure of the human genome, as well as that of several model organisms, is the key to our understanding how genes fu- tion in health and disease. With the combined development of innovativetools, resources, scientific know-how, and an overall functional genomic strategy, the origins of human and other organisms’geneticdiseases can be traced. Scientificresearch groups and dev- opmental departments of several major pharmaceutical and biotechnological companies are using new, innovative strategies to unravel how genes function, elucidating the gene protein product, understanding how genes interact with others-both in health and in the disease state. Presently, the impact of the applications of genome research on our society in medicine, agriculture and nutrition will be comparable only to that of communication technologies. In fact, computational methods, including networking, have been playing a substantial role even in genomics and proteomics from the beginning. We can observe, however, a fundamental change of the paradigm in life sciences these days: research focused until now mostly on the study of single processes related to a few genes or gene products, but due to technical developments of the last years we can now potentially identify and analyze all genes and gene products of an organism and clarify their role in the network of lifeprocesses.

Editors and Affiliations

  • Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Sándor Suhai

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