Skip to main content
SpringerLink
Log in

Cytokines, Stress, and Depression

  • Book
  • © 1999

Overview

Editors:
  1. Robert Dantzer

    1. INRA-INSERM, Bordeaux, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Emmanuelle E. Wollman

    1. CNRS, Paris, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Raz Yirmiya

    1. The Hebrew University of Jerusalem, Jerusalem, Israel

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 461)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (18 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Depression and Immunity

    1. Immune Correlates of Depression

      • Michael Irwin
      Pages 1-24

    2. Major Depression and Activation of The Inflammatory Response System

      • Michael Maes
      Pages 25-46

    3. Cytokine Production in Depressed Patients

      • Andreas Seidel, Matthias Rothermundt, Lothar Rink
      Pages 47-57

    4. Indicators of Immune Activation in Depressed Patients

      • Anna Sluzewska
      Pages 59-73

  3. Brain Effects on Cytokines

    1. Mood and Cognitive Disorders in Cancer Patients Receiving Cytokine Therapy

      • Christina A. Meyers
      Pages 75-81

    2. Mechanisms of the Behavioural Effects of Cytokines

      • Robert Dantzer, Arnaud Aubert, Rose-Marie Bluthé, Gilles Gheusi, Sandrine Cremona, Sophie Layé et al.
      Pages 83-105

    3. Effects of Cytokines on Glucocorticoid Receptor Expression And Function

      • Andrew H. Miller, Carmine M. Pariante, Bradley D. Pearce
      Pages 107-116

    4. Effects of Cytokines on Cerebral Neurotransmission

      • Adrian J. Dunn, Jianping Wang, Tetsuya Ando
      Pages 117-127

    5. Inflammation and Brain Function under Basal Conditions and During Long-Term Elevation of Brain Corticotropin-Releasing Hormone Levels

      • Astrid C. E. Linthorst, Johannes M. H. M. Reul
      Pages 129-152

  4. Effects of Stress on Cytokine Production and Actions

    1. Dynamic Regulation of Proinflammatory Cytokines

      • Linda R. Watkins, Kien T. Nguyen, Jacqueline E. Lee, Steven F. Maier
      Pages 153-178

    2. Cross-Sensitization Between Immune And Non-Immune Stressors

      • J. H. Tilders, E. D. Schmidt
      Pages 179-197

  5. Effects of Cytokines and Cytokine Antagonists in Animal Models of Depression

    1. Anhedonic and Anxiogenic Effects of Cytokine Exposure

      • Hymie Anisman, Zul Merali
      Pages 199-233

    2. Stress, Learned Helplessness, and Brain Interleukin-1β

      • Steven F. Maier, Kien T. Nguyen, Terrence Deak, Erin D. Milligan, Linda R. Watkins
      Pages 235-249

    3. Stress, Depression, and The Role of Cytokines

      • B. E. Leonard, Cai Song
      Pages 251-265

  6. Effects of Antidepressants Cytokine Production and Action

    1. Is There Evidence for an Effect of Antidepressant Drugs on Immune Function?

      • Pierre J. Neveu, Nathalie Castanon
      Pages 267-281

    2. Cytokines, “Depression Due to A General Medical Condition,” and Antidepressant Drugs

      • Raz Yirmiya, Joseph Weidenfeld, Yehuda Pollak, Michal Morag, Avraham Morag, Ronit Avitsur et al.
      Pages 283-316

    3. Cytokines, Stress, and Depression

      • Robert Dantzer, Emmanuelle E. Wollman, Ljubisa Vitkovic, Raz Yirmiya
      Pages 317-329

    4. Correction to: Cytokines, “Depression Due to A General Medical Condition,” and Antidepressant Drugs

      • Robert Dantzer, Emmanuelle E. Wollman, Raz Yirmiya
      Pages C1-C1

  7. Back Matter

    Pages 331-336
    Download chapter PDF
Back to top

Keywords

About this book

Cytokines had been characterized in the early eighties as communication mole­ cules between immune cells, and between immunocytes and other peripheral cells, such as fibroblasts and endothelial cells. They play a key role in the regulation of the immune response and the coordination of the host response to infection. Based on these biological properties, nobody would have predicted that one decade later cytokines would burst upon neurosciences and permeate into several avenues of current research. In neurology, the connection between cytokines and inflammation, and the demonstration of a pivotal role of some of these molecules in cell death by apoptosis, prompted the investigation of their involvement in several neurological diseases involving an inflammatory component, including multiple sclerosis, brain trauma, stroke, and Alzheimer's disease. This movement started in the late eighties, and the corresponding field of research, known as neuroimmunology, is presently booming. In psychiatry, however, the relationship between cytokines and mental disorders was much less evident and took longer to materialize. The first indication that cytokines might be involved in psychopathology came from cancerology and internal medicine.

Editors and Affiliations

  • INRA-INSERM, Bordeaux, France

    Robert Dantzer

  • CNRS, Paris, France

    Emmanuelle E. Wollman

  • The Hebrew University of Jerusalem, Jerusalem, Israel

    Raz Yirmiya

Bibliographic Information

  • Book Title: Cytokines, Stress, and Depression

  • Editors: Robert Dantzer, Emmanuelle E. Wollman, Raz Yirmiya

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/b102345

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1999

  • Hardcover ISBN: 978-0-306-46135-4Published: 31 July 1999

  • Softcover ISBN: 978-1-4757-8610-1Published: 23 March 2013

  • eBook ISBN: 978-0-585-37970-8Published: 23 November 2007

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XII, 338

  • Topics: Neurology, Pharmacology/Toxicology, Neurosciences

Publish with us

Policies and ethics

Back to top

Search

Navigation