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Mouse Models in the Study of Genetic Neurological Disorders

  • Book
  • © 1999

Overview

Editors:
  1. Brian Popko

    1. University of North Carolina at Chapel Hill, Chapel Hill, USA

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Part of the book series: Advances in Neurochemistry (ANCH, volume 9)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-xviii
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  2. An Overview of Mouse Models in Neuroscience Research

    • Brian Popko
    Pages 1-24

  3. X-Linked Dysmyelination: Mouse Models of Pelizaeus—Merzbacher Disease

    • Klaus-Armin Nave
    Pages 25-41

  4. Charcot-Marie-Tooth Disease: Pathology, Genetics, and Animal Models

    • Ueli Suter
    Pages 43-62

  5. Mouse Mutations in the Study of Cerebellar Development

    • Domna Karagogeos, Ourania Pavlou
    Pages 63-97

  6. The Role of Neurotrophic Factors in Development and Neurodegenerative Disorders

    • William D. Snider, Inmaculada Silos-Santiago
    Pages 99-118

  7. Transgenic Mice with Neurofilament Abnormalities

    • Carmen Lampron, Sébastien Couillard-Després, Jean-Pierre Julien
    Pages 119-135

  8. Mouse Models of Amyotrophic Lateral Sclerosis

    • Toni L. Williamson, W. Don Cleveland
    Pages 137-162

  9. Transgenic Mouse Models of CAG Trinucleotide Repeat Neurologic Diseases

    • Harry T. Orr, Huda Y. Zoghbi
    Pages 163-185

  10. Alzheimer%#x2019;s Disease and Genetically Engineered Animal Models

    • David R. Borchelt, Philip C. Wong, Sangram S. Sisodia, Donald L. Price
    Pages 187-214

  11. Model of Genetic Susceptibility to Late-Onset Alzheimer’s Disease: Mice Transgenic for Human Apolipoprotein E Alleles

    • Donald E. Schmechel, Pu-Ting Xu, John R. Gilbert, Allen D. Roses
    Pages 215-243

  12. Lysosomal Disorders

    • Kunihiko Suzuki, Marie T. Vanier, Kinuko Suzuki
    Pages 245-283

  13. Neurological Implications of the Genetic Mouse Models for Human Phenylketonuria and Hyperphenylalaninemia

    • J. David Mcdonald
    Pages 285-295

  14. Mouse Models of down Syndrome

    • Muriel T. Davisson, Alberto C. S. Costa
    Pages 297-327

  15. Modeling Epileptic Disorders in Mice

    • Thomas N. Seyfried, Michael Poderycki, Mariana Todorova
    Pages 329-359

  16. Back Matter

    Pages 361-366
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Keywords

About this book

The number of mouse models that are available for the study of human genetic neurological disorders is large and growing rapidly. Therefore, it was difficult to select the models that were reviewed in this volume. Clearly, there are important models that are not discussed, and perhaps a volume twice this size would have been more appropriate. Moreover, the pace at which new models are being developed and analyzed is rapid. As this volume goes to press, I am sure that additional mouse genes responsible for naturally occurring neurological disorders are being discovered and that many new transgenic and mutant mouse strains are being developed. Therefore, this volume should not be viewed as a comprehensive compendium, but rather as an update of work in progress. It is exhilarating to witness the fast pace at which these models are being established as important tools in the study of basic neuroscience and neurological disorders. It will be even more exciting to see their utilization in the development and testing of therapeutic interventions for these diseases. I would like to thank each of the authors who have contributed to this volume for their time and their expertise. I would also like to thank Drs. Timothy Coetzee and Joshua Corbin for their advice in the selection of the topics covered. I am deeply indebted to Dr. Kunihiko Suzuki, who first approached me with the idea for this volume, for his guidance throughout its preparation.

Editors and Affiliations

  • University of North Carolina at Chapel Hill, Chapel Hill, USA

    Brian Popko

Bibliographic Information

  • Book Title: Mouse Models in the Study of Genetic Neurological Disorders

  • Editors: Brian Popko

  • Series Title: Advances in Neurochemistry

  • DOI: https://doi.org/10.1007/978-1-4615-4887-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1999

  • Hardcover ISBN: 978-0-306-45965-8Published: 28 February 1999

  • Softcover ISBN: 978-1-4613-7217-2Published: 08 October 2012

  • eBook ISBN: 978-1-4615-4887-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVIII, 366

  • Topics: Neurosciences, Human Genetics

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