Cell Adhesion Molecules

1. Front Matter

   Pages i-x

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2. Transcriptional Regulation of the αIIβ Integrin Gene

   • Gerard Marguerie, Georges Uzan

   Pages 1-11

3. Integrin Expression and Epithelial Cell Differentiation

   • Vito Quaranta

   Pages 13-27

4. Fibronectin Mutations in Mice

   • Elisabeth N. Georges, Elizabeth L. George, Helen Rayburn, Richard O. Hynes

   Pages 29-39

5. General Discussion -- Session I

   • Martin E. Hemler, Enrico Mihich

   Pages 41-43

6. Regulation of β1 Integrin-Mediated Adhesive Functions

   • Francisco Sánchez-Madrid, Alicia G. Arroyo, Miguel R. Campanero, Paloma Sánchez-Mateos

   Pages 45-61

7. Elements for a Structural/Functional Model of Human Platelet Plasma Membrane Fibrinogen Receptor, the Glycoprotein IIb/IIIa Complex (Integrin αIIb/β3)

   • Juan José Calvete

   Pages 63-91

8. Extracellular and Intracellular Functions of vla Proteins

   • Martin E. Hemler, Akihide Masumoto, Bosco M. C. Chan, Paul Kassner, Joaquin Teixidó

   Pages 93-104

9. Signal Transduction from Leukocyte Integrins

   • Eric J. Brown

   Pages 105-125

10. Coordinate Role for Proteoglycans and Integrins in Cell Adhesion

    • James B. McCarthy, Amy P. N. Skubitz, Leo T. Furcht, Elizabeth A. Wayner, Joji Iida

    Pages 127-147

11. Adhesion Molecules at Endothelial Cell to Cell Junctions

    • Maria Grazia Lampugnani, Massimo Resnati, Marco Raiteri, Marco Pittiglio, Luigi Ruco, Elisabetta Dejana

    Pages 149-163

12. Regulation of T Cell Adhesion with T Cell Differentiation and with Acute Activation by Mip-lβ Cytokine Immobilized on CD44 Proteoglycan

    • Yoshiya Tanaka, David H. Adams, Tamas Schweighoffer, Stephen Shaw

    Pages 165-179

13. Activation of Lfa-1: The L16 Epitope is a Cation-Binding Reporter

    • Carl G. Figdor, Yvette van Kooyk

    Pages 181-194

14. Activation-Dependent Regulation of β1 Integrin Expression and Function in Human Natural Killer Cells

    • Angela Gismondi, Fabrizio Mainiero, Gabriella Palmieri, Stefania Morrone, Michele Milella, Mario Piccoli et al.

    Pages 195-208

15. Interaction of Cytotoxic T Lymphocytes with Autologous Melanoma: Role of Adhesion Molecules and β1 Integrins

    • Andrea Anichini, Roberta Mortarini, Giorgio Parmiani

    Pages 209-219

16. Tumor Cell-Endothelial Cell Interactions During Blood Borne Metastasis: Role of Specific Adhesion, Motility, and Growth Molecules

    • Garth L. Nicolson, Timothy J. Yeatman, Robert J. Tressler, Timothy V. Updyke, Jun-ichi Hamada, Phillip G. Cavanaugh

    Pages 221-243

17. Adhesion Mechanisms in Lymphoma and Carcinoma Metastasis

    • Geertje La Rivière, Hans Kemperman, Mariëtte Driessens

    Pages 245-264

18. Cd44 and Splice Variants of Cd44 in Normal Differentiation and Tumor Progression

    • Peter Herrlich, Wolfgang Rudy, Martin Hofmann, Robert Arch, Margot Zöller, Volker Zawadzki et al.

    Pages 265-288

19. Back Matter

    Pages 289-294

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The Fourth Annual Pezcoller Symposium entitled Adhesion Molecules: Cellular Recognition Mechanisms was held in Rovereto, Italy, June 24-26, 1992 and was focussed on the detailed mechanisms whereby cells utilize certain integral membrane proteins to perceive their surrounding environment and interact with it. With timely presentations and stimulating discussions this Symposium addressed the genetics and biochemistry of adhesion molecules, the regulation of their functions and their role in cancer and the immune system. Emphasis was given to adhesion proteins in the integrin family because of the widespread distribution of this group of molecules and its important role in essentially all eukaryotic biological systems. The regulation of integrin genes and their expression are discussed in detail, as are specific aspects of the genetics of fibronectin. The molecular basis for the regulation of certain integrins, the function of these proteins in determining cell adhesion, and the consequences of this adhesion for the function of the cells involved are discussed. The role of certain integrins in stimulating signal transduction, the essential involvement of integrins in conditioning the function of T and NK cells function, the heterogeneity of integrins and its biological consequences, and the role of cell adhesion molecules in tumor cells invasion and metastases are all extensively analyzed. New information was presented on the role of CD44 and splice variants in normal differentiation and tumor progression.

• Activation
• Immune System
• biochemistry
• carcinoma
• genes
• genetics
• proteins
• proteoglycans
• regulation
• signal transduction

• Dana-Farber Cancer Institute, Boston, USA

  Martin E. Hemler

• Roswell Park Cancer Institute, Buffalo, USA

  Enrico Mihich

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