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Advances in Experimental Medicine and Biology

Regulation of Inflammatory Signaling in Health and Disease

Editors: Xu, Dakang (Ed.)

  • Covers cutting-edge research in innate immunity
  • Reviews novel mechanisms in regulation of inflammation, such as microRNA and epigenetics
  • Discussing newly emerged innate lymphoid cells, which bridges innate and adaptive immunity 
  • Written by experts in this field
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eBook $149.00
price for USA (gross)
  • ISBN 978-981-10-5987-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-981-10-5986-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book discusses recent research in innate immunity, which has revealed a large number of receptors that sense the presence of microorganisms or cellular damage in tissues. In complex tissues, many of these sensing events occur simultaneously. Thus, the downstream signaling pathways need to be integrated so that an appropriate cellular inflammatory response can be initiated. In addition, the inflammasome defines the molecular and cellular processes of inflammation in response to microbial infection. Previous data suggested that regulation of inflammasomes is mediated by microbes, but inflammasomes also have antimicrobial functions. Increasing evidence in mouse models, together with human data, strongly implicates an involvement of the inflammasome and uncontrolled inflammation in the initiation and progression of diseases with a high impact on public health. 

The book reviews novel aspects of functional genomics, epigenomics, transcriptomics, post-translat

ional modifications, microbiome and immunometabolism in order to understand inflammatory signaling and responses, covering recent findings on the mechanisms underlying the regulation of inflammatory responses to pathogens, dysregulation of these responses in inflammatory disease, and the use of such mechanisms to boost or subdue the inflammatory response. Bridging the gaps in understanding between the fields of human and mouse immunology, it provides valuable insights into inflammatory-mediated disease and immune defense. Such innovative perspectives in both basic and clinical research promote the translation of knowledge to the clinic.

About the authors

Dr. Dakang Xu is Professor at Shanghai Jiao Tong University and Institute of Ageing Research, Hangzhou Normal University, China. The main focus of his research team is to used a combination of genetically modified mouse models of disease, cell signalling, bioinformatics

analyses and clinical applications, to understand the mechanisms of regulation of epigenetic factors in inflammatory signalling. He has also studied how modulation of the activity of those key factors affects the inflammatory response and tumour progression, through the function of immune cell subsets and cytokines in cancer and inflammatory diseases. This work has led to 50 peer-reviewed publications in high impact journals, including Nature ImmunologyImmunityNature CommunicationsPNAS and Cancer Research

Table of contents (1 chapters)

  • Posttranslational Modification Control of Inflammatory Signaling

    Yibo Si, et al.

    Pages

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-981-10-5987-2
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-981-10-5986-5
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Regulation of Inflammatory Signaling in Health and Disease
Editors
  • Dakang Xu
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1024
Copyright
2017
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-10-5987-2
DOI
10.1007/978-981-10-5987-2
Hardcover ISBN
978-981-10-5986-5
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XII, 244
Number of Illustrations and Tables
1 b/w illustrations, 18 illustrations in colour
Topics