Advances in Experimental Medicine and Biology

RNA Activation

Editors: Li, Long-Cheng (Ed.)

  • Provides a comprehensive knowledge of RNA activation
  • Chapters highlight recent advances in specific topics
  • Refers to several kinds of cancer
  • Contributed by world recognized experts in this field
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eBook $149.00
price for USA (gross)
  • ISBN 978-981-10-4310-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-981-10-4309-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

This book offers an essential guide to RNA activation (RNAa), an emerging and fascinating new field. RNAa is a small RNA-guided and Argonaute-dependent gene regulation phenomenon in which promoter-targeted short double-stranded RNAs (dsRNAs) induce target gene expression at the transcriptional level. It occurs primarily in the nucleus and can be mediated by artificially designed short duplex RNAs that target regulatory sequences (e.g., promoters, genes’ 3’ termini and enhancers) and naturally occurring small RNAs (e.g., miRNAs and C. elegans 22G-RNAs).

With contributions from internationally respected RNA experts, this book provides comprehensive coverage of different RNAa mechanisms and a timely update on recent advances in RNAa research, with a focus on developing RNAa-based therapeutics. Special chapters are also devoted to the topics of gene activation induced by antisense oligonucleotides and the CRISPR system. As the first book to cover RNAa, it will be of interest to a wide audience, from scientists in academia and the pharmaceutical industry to clinicians who wish to further explore the biology of RNAa and related phenomena, so as to harness their full potential for use in biotechnology and drug development.

About the authors

Dr. Long-Cheng Li is a professor at Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Table of contents (16 chapters)

  • Small RNA-Guided Transcriptional Gene Activation (RNAa) in Mammalian Cells

    Li, Long-Cheng

    Pages 1-20

  • Enhancing Neuronogenesis and Counteracting Neuropathogenic Gene Haploinsufficiencies by RNA Gene Activation

    Mallamaci, Antonello

    Pages 23-39

  • Target-Recognition Mechanism and Specificity of RNA Activation

    Cao, Huiqing (et al.)

    Pages 41-51

  • Promoter-Targeted Small Activating RNAs Alter Nucleosome Positioning

    Wang, Bin (et al.)

    Pages 53-61

  • Endogenous miRNAa: miRNA-Mediated Gene Upregulation

    Huang, Vera

    Pages 65-79

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-981-10-4310-9
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $189.00
price for USA
  • ISBN 978-981-10-4309-3
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
RNA Activation
Editors
  • Long-Cheng Li
Series Title
Advances in Experimental Medicine and Biology
Series Volume
983
Copyright
2017
Publisher
Springer Singapore
Copyright Holder
Springer Nature Singapore Pte Ltd.
eBook ISBN
978-981-10-4310-9
DOI
10.1007/978-981-10-4310-9
Hardcover ISBN
978-981-10-4309-3
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIV, 239
Number of Illustrations and Tables
7 b/w illustrations, 38 illustrations in colour
Topics